PPubMed15 Apr 2025Cited 5×

Balancing ethical data sharing and open science for reproducible research in biomedical data science

Dmitrijs Lvovs, Allison L. Creason, Stuart S. Levine, Michael Noble, Anup Mahurkar, Owen White, Elana J. Fertig

Abstract

'Anup Mahurkar' 'Owen White' 'Elana J. Fertig'] Analyses of large-scale health data in biomedical data science can help uncover new treatments and deepen our understanding of disease and fundamental biology. Here we examine the balance between ethical and responsible data sharing and open science practices that are essential for reproducible research in biomedical data science.

A figure from Balancing ethical data sharing and open science for reproducible research in biomedical data science — fig. from the paper

§ The Valyu brief

The paper, in five minutes

Read from the full text via Valyu Contents

Balancing ethical data sharing with open science is essential for reproducible biomedical research.

What’s new

i.Identifies ethical and privacy challenges in biomedical data sharing.
ii.Emphasizes the role of metadata tracking and batch‑effect mitigation for data quality.
iii.Reviews open‑source tools and platforms that support reproducible research.
iv.Proposes a framework for balancing open science with patient confidentiality.

How they did it

The authors performed a literature‑based review, synthesizing guidelines, standards, and examples from recent biomedical data‑science initiatives. They evaluated ethical, technical, and infrastructural aspects of data sharing and reproducibility. The discussion integrates perspectives on policy, metadata standards, and software tools.

Caveats

✕Implementation of comprehensive metadata standards can be burdensome for researchers.
✕Sustaining open‑source software development lacks stable funding.
✕Resource‑intensive data harmonization may limit adoption in smaller projects.
✕Incidental findings raise unresolved ethical questions about patient notification.

§ The Valyu brief

Reading the full paper and taking notes. This takes a few seconds…

§ Ask this paper

Ask a question about this paper

Valyu reads the full text and answers from what the paper actually says.

§ Related work in other archives

Similar papers in all four archives

The same idea searched in arXiv, PubMed, bioRxiv and chemRxiv at once, so a method can lead you to where it is being applied.

AarXiv4 found

PPubMed3 found

BbioRxiv4 found

CchemRxiv4 found

Searching the other archives…