Volume P · since 1996
PubMed
Full-text biomedical literature from PubMed Central, from clinical trials to cell biology.
Biomedicine · Life Sciences
Newest strong work in PubMed
Volume P · since 1996
Full-text biomedical literature from PubMed Central, from clinical trials to cell biology.
Biomedicine · Life Sciences
Newest strong work in PubMed
Manuel Weber, Leah Trumet, Fabienne Lange, Julia Murk + 8 more
Purpose Combination immunotherapy has shown encouraging activity across multiple solid tumors. We report the complete and consecutive cohort of patients with locally advanced oral squamous cell carcinoma (OSCC) treated at a single center within the prospective, multicenter, randomized phase 2 BelieveIT-201 trial…
Amanda G. Iglesias, Jasmine K. Bhatti, Alexandra E. Turfe, Stephen Chang + 3 more
The paraventricular nucleus of the thalamus (PVT) has emerged as an important node in circuits regulating motivated behavior. The neuronal pathway from the lateral hypothalamus (LH) to the PVT has been shown to regulate arousal, feeding, and reward seeking. However, the involvement of the LH-PVT pathway in individual…
Yuling Zhu, Yunfei Hu, Manfei Bella Xie, Haoran Qin + 7 more
Spatial transcriptomics enables the quantification of gene expression within its native tissue context, providing unprecedented insight into tissue architecture, cellular ecosystems, and local cell-cell interactions at regional and single-cell resolution. Accurate cell type annotation is a critical prerequisite for…
Jillian Cwycyshyn, Cooper Stansbury, Sarah Golts, Hyunsu Lee + 4 more
Title: Summary Direct reprogramming of human fibroblasts into hematopoietic stem cells (HSCs) offers a promising strategy for generating autologous cells to treat blood and immune disorders. Current protocols are limited by low efficiency and insufficient tools for evaluating reprogramming outcomes. Although functional…
Mengmeng Liu, Yichen Zhu, Hemiao Liang, Yu Li + 2 more
Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatial multi-omics have uncovered their substantial functional…
Jing Liu, Zhegang Zhang, Jiayou Zhang, Xuanxuan Nian
Influenza vaccine effectiveness exhibits significant heterogeneity across age groups, largely shaped by lifelong immune remodeling. This review adopts a continuous spectrum perspective-spanning immune development, immune maturation, and immunosenescence-to delineate host immune responses to influenza across different…
Camila C. S. Caetano, David A. Prots, Matthew H. Thomas, Dylan R. Micallef + 2 more
Seasonal influenza vaccines provide variable protection against antigenically drifted influenza A (H1N1 and H3N2) and influenza B viruses. Broadly protective approaches using computationally optimized broadly reactive antigens (COBRAs) can enhance immunity against diverse strains. Bis-(3′,5′)-cyclic dimeric adenosine…
Dario Rusciano
Cancer vaccines have resurged in oncology because they address a central question in precision medicine: whether the molecular identity of a tumor can be converted into an immune target that is both specific and clinically useful. Preventive vaccines against oncogenic viruses have already shown that immune intervention…
Da-Yo Yuh, Chi-Ju Yao, Chia-Yu Chen, Ching-Yi Wu + 9 more
Title: Summary Ameloblastoma (AM) is a locally aggressive odontogenic epithelial tumor with poorly understood intraosseous pathogenesis. Here, we established an orthotopic intraosseous mouse model using AM epithelial cells in combination with AM-derived mesenchymal stromal cells (AMMSCs) or their secretome.…
Yuna Sato, Yutaro Yamamoto, Ammar Abdurrahman Hasyim, Takeshi Morita + 8 more
Multi pathogen vaccines have emerged as a promising strategy to improve vaccine coverage, simplify immunization logistics, and address overlapping global health threats. However, few vaccine platforms have demonstrated robust and durable immune responses against pathogens spanning distinct biological classes. Here, we…
Reza Gheitasi, Mahnaz Rezaei, Parvaneh Nafisi Fard, Daniela Roel + 8 more
Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio earlier and more severely than females. We…
Sixuan Chen, Liping Tu, Quanhua Chen
The field of spatial pharmacology has emerged as a critical framework for understanding the complex interactions between anti-cancer immunomodulators, tumor cells, and the tumor microenvironment (TME) at single-cell resolution. This review synthesizes the theoretical foundations, historical evolution, clinical…
Ziyan Xie, Musashi Yamakawa, Tasuku Kayama, Takuya Sasaki + 1 more
Interoceptive signals reflecting internal bodily states influence emotional processing. The paraventricular thalamus (PVT) constitutes a key node within the interoceptive network, monitoring circulating humoral factors in the ventricles, and is thus considered to link interoceptive signals to emotion-related behaviors.…
Guoxia Wen, Jiaqi Li, Hanyu Wu, Jialing Fang + 9 more
To streamline the application of sequence-based DL methods in single-cell genomics, we established a two-layer CNN as our baseline model. We focus our benchmark on how data characteristics, hyperparameter optimization, and advanced model architectures impact performance across sequence-to-expression and…
Emmelie Eckhardt, Josephine Friedrich, Wiebke Lange, Julia Sehl-Ewert + 4 more
Adjuvants function as an enhancer and activator of the immune response and can be of pivotal importance for the efficacy of vaccines. AS01, which is a liposome formulation spiked with the saponin derivate QS-21 and the detoxified lipopolysaccharide MPL-A, and AS03, which is a squalene-based oil in water emulsion that…
Jiangyou Shi, Rongchun Chen
Osteosarcoma exhibits limited responsiveness to immune checkpoint blockade, a feature commonly referred to as immune coldness. However, interpreting immune coldness as a fixed tumour trait may underestimate the spatially and temporally dynamic processes that govern immune resistance. Accumulating evidence instead…
Zhiqun Bai, Zhiguang Chen
Glioblastoma (GBM) has a high rate of post-surgical recurrence, which can be attributed to residual tumor cells as well as to the disruption of the tumor microenvironment (TME) caused by surgery. Here, we define the postoperative cavity microenvironment (POCM) as a pathological niche with distinct spatial and temporal…
Naosuke Hoshina, Joshua M. Boeckers, Erin M. Johnson-Venkatesh, Miyuki Hoshina + 8 more
The basal ganglia (BG) contain multiple parallel neural circuits, each of which may control different behaviors. However, how the distinct parallel BG circuits are molecularly organized is not known. Here, we show that two δ2-protocadherins (PCDHs), PCDH17 and PCDH10, which are homophilic cell adhesion molecules…
Yicong Huang, Ali Shamsnia, Mengze Chen, Shuang Wu + 3 more
Ramping neural activity is widely interpreted as a signature of predictive processing, but whether these signals truly reflect predictions or instead emerge from sensory mechanisms remains unclear. To address this question, we used two-photon calcium imaging across multiple cell types in visual and parietal cortex…
Haiqin Zhang, Jian Zhang, Chen Su, Yanming Wang + 8 more
Objective/background To evaluate the impact of Spatially Fractionated Radiation Therapy (SFRT) on symptomatic relief and survival outcomes in patients with large-volume tumors. Methods A total of 60 cancer patients who received SFRT between February 2023 and May 2025 were analyzed in this retrospective study. Collected…