Statin Therapy Protects White Matter in Cerebral Small Vessel Disease Independent of Lipid‐Lowering: Biomarker and Neuroimaging Evidence

Abstract

4## Discussion This study found that age and hypertension remain the most significant risk factors for CSVD. As the study cohort excluded patients using statins for central nervous system indications, the intergroup differences observed in statin use likely originated from their prescriptions for managing conditions such as hypertension and atherosclerosis and thus may lack clinical significance. The key finding of this research is that, specifically within the CSVD group, statin therapy demonstrated significant associations with Fazekas scores, serum myelin basic protein levels, and bilateral