Gut microbial diversity and candidate keystone taxa in Indian tribes: Insights across lifestyle-ecological continuum and health associations
Sahid Afrid Mollick, Gin Khan Khual, Ankita Ghosh, Shiv Kumar Patel, Subhra Bhattacharyya, Chandra Sekhar Roy, Anwesh Maile, Hampapathalu Adimurthy Nagarajaram, Moajungla Longkumer, Mopada Nani Babu, Anup Raj Kundapur, Saloni Uniyal, Arna Chattterjee, Maitrayee Mitra, Mithun Sikdar, B.P. Urade, Venugopal N. Pulamaghatta
Abstract
Title: Highlights 1. • An introduced analytical framework quantifies taxon-community associations to identify computationally inferred candidate keystone taxa. 2. • Application to five PVTGs identifies 121 candidate keystone taxa, most of which are population-specific, with a reproducible subset across traditional populations. 3. • Several candidate keystone taxa associated with lower community dispersion also show consistent associations with multiple disease conditions, highlighting priorities for future investigation. 4. • A conserved metabolic core coexists with population-specific functions, while acculturation is associated with reduced microbial diversity and increased disease-associated taxa.
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