Sheng Wang, Xiaoyong Duan, Yulin Zou, Jianxiong Gui
Abstract
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IgM paraprotein can falsely raise calcium and lower sodium on certain lab platforms, causing diagnostic delays unless interference is investigated.
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How they did it
The authors compared electrolyte results from two analytical platforms and performed direct ion‑selective electrode measurements. They conducted dilution studies, polyethylene glycol precipitation, reaction‑curve inspection, and simulation experiments to uncover the interference mechanism. These steps linked the laboratory discrepancy to IgM paraprotein precipitation.
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