RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations

Abstract

'Florian Markowetz'] Visualization and analysis of molecular networks are both central to systems biology. However, there still exists a large technological gap between them, especially when assessing multiple network levels or hierarchies. Here we present RedeR, an R/Bioconductor package combined with a Java core engine for representing modular networks. The functionality of RedeR is demonstrated in two different scenarios: hierarchical and modular organization in gene co-expression networks and nested structures in time-course gene expression subnetworks. Our results demonstrate RedeR as a new framework to deal with the multiple network levels that are inherent to complex biological systems. RedeR is available from [http://bioconductor.org/packages/release/bioc/html/RedeR.html]().