Comments on "Human Dominant Disease Genes Are Enriched in Paralogs Originating from Whole Genome Duplication"

Abstract

We previously showed that monogenic disease genes (MDs) are enriched in duplicates and hypothesized that functional redundancy among duplicates underlies this enrichment . In their comment, Singh et al. refine this enrichment to genes resulting from whole genome duplications (WGDs) ; they, furthermore, “could not find any significant enrichment in duplicates in support of possible functional compensation for essential genes” by using gene essentiality data from mouse (transferred to human through orthology). We appreciate the scientific argument, but we would like to point out that confounding