Quantitative mapping of the per‐axon diffusion coefficients in brain white matter Quantitative Mapping of the Per‐Axon Diffusion Coefficients Kaden et al.

Abstract

It is difficult, if not impossible, to examine the axon microgeometry using markers that are affected by fiber dispersion and crossing, which are ubiquitous in brain white matter. The present article has introduced SMT to disentangle the per-axon diffusion process from the fiber orientation distribution. This method does not make use of prior knowledge about how the fibers are oriented inside a voxel, which is normally not available in advance. Here we have demonstrated SMT in the cerebral white matter of a live human subject and provided quantitative maps of the voxel-averaged diffusion coeff