PPubMed8 Dec 2017Cited 35×

Cortical Afferents and Myeloarchitecture Distinguish the Medial Intraparietal Area (MIP) from Neighboring Subdivisions of the Macaque Cortex Connections of Macaque Medial Intraparietal Sulcus

Sophia Bakola, Lauretta Passarelli, Tony Huynh, Daniele Impieri, Katrina H. Worthy, Patrizia Fattori, Claudio Galletti, Kathleen J. Burman, Marcello G. P. Rosa

Abstract

'Katrina H. Worthy' 'Patrizia Fattori' 'Claudio Galletti' 'Kathleen J. Burman' 'Marcello G. P. Rosa'] Title: Visual Abstract

A figure from Cortical Afferents and Myeloarchitecture Distinguish the Medial Intraparietal Area (MIP) from Neighboring Subdivisions of the Macaque Cortex Connections of Macaque Medial Intraparietal Sulcus — fig. from the paper

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The study refines the subdivision of macaque medial intraparietal cortex (MIP) using connectivity and myeloarchitecture, distinguishing it from neighboring areas.

What’s new

i.Proposed a refined subdivision of the medial intraparietal cortex based on connectivity and myeloarchitecture
ii.Mapped corticocortical connections of nine tracer injection sites in macaque medial intraparietal sulcus
iii.Showed that V6Ad and MIP share ~90% of labeled neurons while also having distinct projection patterns
iv.Provided statistical evidence of concordance across cases (Rs, W values)
v.Offered an anatomic scheme to guide future functional studies of the parietal reach region

How they did it

The authors performed retrograde tracer injections (CTB, DY, FB, FE, FR) into nine sites within V6Ad and MIP of macaque monkeys, then quantified labeled neurons across cortical areas. They combined myeloarchitectural criteria with statistical analyses (correlation, chi‑square, concordance tests) to assess connection patterns.

What they found

Correlation of V6Ad injection pattern: Rs = 0.733, df = 7, p = 0.02
Concordance of MIP cases 3‑7: W = 0.724, χ² = 28.96, df = 8, p = 3 × 10⁻⁴
Reciprocal V6Ad‑MIP and common extrinsic projections accounted for ~90% of total labeled neurons (range 82‑98% per case)
Distribution of label across cases 1‑7 showed moderate concordance: W = 0.594, χ² = 33.29, df = 8, p = 5 × 10⁻⁵
Data from case 8 were excluded from further analyses due to tracer spill into area PE

Caveats

✕Tissue damage and proximity of injections to neighboring areas reduced certainty in defining MIP boundaries
✕Case 8 data were excluded, limiting completeness of the MIP analysis
✕Some injection sites lack complete species/sex/weight information
✕Only retrograde labeling was reported for FE and FR tracers, limiting assessment of anterograde connections

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Cortical Afferents and Myeloarchitecture Distinguish the Medial Intraparietal Area (MIP) from Neighboring Subdivisions of the Macaque Cortex Connections of Macaque Medial Intraparietal Sulcus

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