Methods for Evaluation of medical prediction Models, Tests And Biomarkers (MEMTAB) 2018 Symposium Utrecht, The Netherlands. 2-3 July 2018

Abstract

Background: As 1.8 million of the 10.4 million people with new TB cases die each year, timely diagnosis and treatment initiation is critical. However, traditional diagnostic methods, such as culture or smear microscopy, are slow or low in sensitivity; more modern techniques, such as sequencing or GeneXpert MTB/RIF, are inaccessible to populations at greatest risk of contracting TB. The WHO has proposed biomarkers as the bases for needed new diagnostic assays to detect active TB. Objectives: To assemble the existing biomarkers and biosignatures used to identify active TB and evaluate the qualit