Characterization and validation of an in vivo confocal Raman spectroscopy led tri‐method approach in the evaluation of the lip barrier BIELFELDT et al.

Abstract

1## INTRODUCTION The lips (labia oris) form an extension from the mucosal membrane to the outer skin. These vermilion borders are the only part of the facial anatomy where the oral mucosa is permanently exposed to the environment.[srt12814-bib-0001] As such they are highly susceptible to environmental exposure, such as wind, sun, smoking, and temperature extremes. Their prominent presence on the face makes them vulnerable to various diseases and a key target for cosmetic and pharmaceutical treatments. Environmental damage as well as certain medications can cause the lips to become dry, chapped