PPubMed28 Apr 2021Cited 22×

Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching

Danielle da Silva Pompeu, Brennda Lucy Freitas de Paula, Antônia Patricia Oliveira Barros, Samir Costa Nunes, Alexandra Melo Pingarilho Carneiro, Jesuína Lamartine Nogueira Araújo, Cecy Martins Silva, Alessandro Loguercio

Abstract

Despite the limitations of this randomized clinical trial, it can be concluded that the association of 10% strontium chloride with PBM (808 nm) was effective in reducing post-bleaching TS; however, it did not differ from the other desensitizing therapies assessed after 21 days of follow-up. S1 Table (DOCX) [Download Media](pone.0250501.s001.docx) Click here for additional data file. S1 Protocol (DOCX) [Download Media](pone.0250501.s002.docx) Click here for additional data file. S2 Protocol (DOCX) [Download Media](pone.0250501.s003.docx) Click here for additional data file. S3 Protocol (DOCX) [

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Combining 10% strontium chloride with photobiomodulation reduces post‑bleaching tooth sensitivity more than placebo, but shows no significant advantage over each treatment alone after 21 days.

What’s new

i.First clinical trial to evaluate combined 10% strontium chloride and photobiomodulation for post‑bleaching tooth sensitivity
ii.Demonstrated that the combination yields the greatest sensitivity reduction after the second week (p ≤ 0.05)
iii.Showed no significant difference between the combination and individual treatments after 21 days (p ≥ 0.05)
iv.Implemented a split‑mouth randomized design with 50 volunteers (25 per group)
v.Provided detailed PBM parameters (808 nm, 100 mW, 1.7 J, 60 J/cm², 16 s per point)

How they did it

Fifty adult volunteers received in‑office bleaching with 35% hydrogen peroxide and were split‑mouth randomized into four groups (placebo, placebo + PBM, strontium, strontium + PBM) with 25 quadrants per group. Photobiomodulation used an 808 nm laser at 100 mW delivering 1.7 J energy (60 J/cm²) for 16 seconds at cervical and apical points. Tooth sensitivity was recorded daily for 21 days using a modified visual analogue scale.

What they found

PBM + STRONTIUM produced the greatest reduction in sensitivity after the second week (p ≤ 0.05)
Placebo + PBM, STRONTIUM, and STRONTIUM + PBM showed no statistical differences in weeks 1 and 3 (p ≥ 0.05)
PLACEBO group experienced the highest sensitivity during the first three days after each bleaching session
Study included 50 volunteers (25 per group) and used 35% H₂O₂ bleaching

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Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching: A split-mouth randomized clinical trial Combination of strontium chloride and photobiomodulation in the control of tooth sensitivity post-bleaching

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