Interpretability of Clinical Decision Support Systems Based on Artificial Intelligence from Technological and Medical Perspective: A Systematic Review

Abstract

'Huan Xiong' 'Yi Lyu' 'Yue Zhou' 'Aijing Luo'] Background Artificial intelligence (AI) has developed rapidly, and its application extends to clinical decision support system (CDSS) for improving healthcare quality. However, the interpretability of AI-driven CDSS poses significant challenges to widespread application. Objective This study is a review of the knowledge-based and data-based CDSS literature regarding interpretability in health care. It highlights the relevance of interpretability for CDSS and the area for improvement from technological and medical perspectives. Methods A systematic search was conducted on the interpretability-related literature published from 2011 to 2020 and indexed in the five databases: Web of Science, PubMed, ScienceDirect, Cochrane, and Scopus. Journal articles that focus on the interpretability of CDSS were included for analysis. Experienced researchers also participated in manually reviewing the selected articles for inclusion/exclusion and categorization. Results Based on the inclusion and exclusion criteria, 20 articles from 16 journals were finally selected for this review. Interpretability, which means a transparent structure of the model, a clear relationship between input and output, and explainability of artificial intelligence algorithms, is essential for CDSS application in the healthcare setting. Methods for improving the interpretability of CDSS include ante-hoc methods such as fuzzy logic, decision rules, logistic regression, decision trees for knowledge-based AI, and white box models, post hoc methods such as feature importance, sensitivity analysis, visualization, and activation maximization for black box models. A number of factors, such as data type, biomarkers, human-AI interaction, needs of clinicians, and patients, can affect the interpretability of CDSS. Conclusions The review explores the meaning of the interpretability of CDSS and summarizes the current methods for improving interpretability from technological and medical perspectives. The results contribute to the understanding of the interpretability of CDSS based on AI in health care.