Cumulative 6-Year Risk of Screen-Detected Ductal Carcinoma In Situ by Screening Frequency Risk of Screen-Detected Ductal Carcinoma In Situ by Screening Frequency Risk of Screen-Detected Ductal Carcinoma In Situ by Screening Frequency
Brian L. Sprague, Shuai Chen, Diana L. Miglioretti, Charlotte C. Gard, Jeffrey A. Tice, Rebecca A. Hubbard, Erin J. Aiello Bowles, Peter A. Kaufman, Karla Kerlikowske
Abstract
Detection of ductal carcinoma in situ (DCIS) is a controversial outcome of mammography screening. The incidence of DCIS increased markedly in the US with the widespread adoption of screening mammography,1,2 and more than 30% of screen-detected breast cancers are DCIS.3 Because DCIS is a nonobligate precursor to invasive breast cancer, the detection and treatment of DCIS may reduce the risk of subsequent invasive disease,4,5 yet there is concern that a substantial fraction of DCIS may never lead to invasive cancer if left untreated.2,6,7 Overdiagnosis is challenging to estimate8,9 but has influ
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