11 papers · ranked by Valyu relevance
Zhen Wang, Wanqun Zheng, Zhen Chen, Shilun Wu + 3 more
'Ming Cai' 'Heping Cai'] Background Recent evidence increasingly suggests key roles for the tricarboxylic acid cycle and fatty acid metabolism in tumor progression and metastasis. Aconitase 2 (ACO2) is a component of the tricarboxylic acid cycle and represents a key cellular metabolic hub that promotes de novo fatty…
Jiaojiao Sun, Bo Xu, Yijing Chen, Meng Sui + 6 more
Mitochondrial dysfunction during lung ischemia-reperfusion injury (LIRI) contributes to organ dysfunction. Aconitase-2 (ACO2), by enhancing the mitochondrial tricarboxylic acid (TCA) cycle in pulmonary vascular endothelial cells (PVECs), plays a critical role in maintaining cellular energy metabolic homeostasis.…
Steven Sun, Scott William Roy, Noelle Anderson
The Aco2 gene of Schizosaccharomyces pombe was formed by gene fusion between curious partners, namely genes encoding the enzyme aconitase and a mitochondrial ribosomal protein. In addition to a full-length transcript, a truncated mRNA encoding only the N-terminal aconitase domain is produced by polyadenylation at an…
Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya + 1 more
Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time for reasons that can be unclear. We find that, in yeast, isozymes are strongly enriched in central carbon metabolism. Using a gene expression…
Amel Yamoune, Marketa Zdarska, Thomas Depaepe, Anna Korytarova + 15 more
The two principal growth regulators cytokinins and ethylene are known to interact in the regulation of plant growth. However, information about underlying molecular mechanism and positional specificity of the cytokinin/ethylene crosstalk in root growth control is scarce. We have identified spatial specificity of…
Jihad Mallat, Mathieu Jozwiak, Nicolás Orozco, Olfa Hamzaoui + 4 more
A fundamental objective of hemodynamic resuscitation is to reverse tissue hypoperfusion and prevent progression to multiorgan failure and death. Conventional tools such as clinical examination, lactate levels, and central or mixed venous oxygen saturation (ScvO₂ and SvO₂, respectively) have intrinsic limitations. These…
Dona M. Gunawardana, Francis Kuang, Simranjeet Kaur, Jordan A. P. McIvor + 9 more
Ethylene is a central plant hormone that orchestrates growth, development, senescence, and stress responses. Because it is gaseous, ethylene must be synthesised on demand, yet the catalytic and regulatory mechanisms of its biosynthetic enzyme, 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), remain poorly…
Arnaldo Dubin, Mario O. Pozo, Edward A. Bittner
According to Fick’s principle, the total uptake of (or release of) a substance by tissues is the product of blood flow and the difference between the arterial and the venous concentration of the substance. Therefore, the mixed or central venous minus arterial CO2 content difference depends on cardiac output (CO).…
Arnaldo Dubin, Mario Omar Pozo
As an expression on Fick’s principle, the reduction in cardiac output is associated with a parallel increase in both mixed venoarterial CO2 content difference (Cmv-aCO2) and arterial-mixed venous oxygen content difference (Ca-mvO2). Nevertheless, disproportioned elevations in Cmv-aCO2 compared to those of Ca-mvO2 ensue…
Fardad Moshtagh Sisan, Christina Joya, Austin Situ, Scott Silver + 1 more
Traditional gas exchange metrics, such as the alveolar-arterial (A–a) gradient (ΔP), fail to account for systemic oxygen extraction or ventilatory adequacy, thereby limiting their diagnostic precision in complex respiratory or circulatory pathologies. We propose and derive the corrected oxygenation gradient (COG), a…
Chihjen Lee, Nikki Chen
Carbon monoxide is a colorless, odorless, and poisonous gas, responsible for approximately 100,000 emergency room visits and over 420 deaths in the U.S. each year. Both carbon monoxide and oxygen bind to the ferrous ions in hemoglobin, but carbon monoxide has a significantly higher affinity. Extensive research has been…