10 papers · ranked by Valyu relevance
Yonatan Amzaleg, Kevin J. McDonnell, Gregory E. Idos, Christina Mathai + 4 more
Variants of uncertain significance (VUS) in mismatch repair (MMR) genes represent a persistent bottleneck in germline interpretation for Lynch syndrome, creating a critical opportunity to leverage tumor biology to refine pathogenicity assessment. Although tumor features such as microsatellite instability (MSI) and…
Yi Ren, Zimei Chen, Hayden Deans, Ying Nian Wu + 1 more
Extensive studies suggest the brain performs Bayesian inference to infer the latent world states. It is a fundamental neuroscience question that how canonical recurrent neural circuits in the brain implement Bayesian inference. Many existing theoretical studies focused on how the recurrent circuits compute the…
Paul B. Conn, Irina S. Trukhanova, Peter L. Boveng, Vladimir Chernook + 1 more
In the springs of 2012-2013, Russian Federation scientists conducted aerial surveys of ice-associated seals (including bearded, ribbon, ringed, and spotted seals) in the Sea of Okhotsk and in Russian waters of the western Bering Sea. These instrument-based surveys used a combination of thermal imaging and digital…
Peter Gill, Helen Johannessen, Christine Børsum, Ane Elida Fonneløp + 1 more
DNA findings on clothing are often evaluated at sub-source level to address whether a person contributed DNA to a sample. In many cases, however, the disputed issue is not whose DNA is present, but how the DNA was transferred. This paper applies the HaloGen framework to evaluate DNA findings on stockings under…
Lou Thomas, Gaia Scerif, Hodo Yusuf, Mackenzie Laird + 3 more
Diffusion decision models (DDMs) offer the potential to go beyond standard accuracy and response-time indices to better understand perceptual decision-making in autism. One unanswered question is whether autistic participants can flexibly adjust the speed and accuracy of their decision-making according to task demands.…
Yasin Topcu, Alper Adak, Halim Can Kayikci, Serkan Aydin + 6 more
Key message Tomato fruit weight is primarily controlled by stable genetic effects and domestication-/improvement-associated loci, including prominent chromosome 5 signals, and integrating SNP, INDEL, and SV diversity improves candidate-locus discovery, biological interpretation, and genomic prediction across…
Huihai Wu, Ashleigh Lister, Iain Macaulay, Katie Long + 10 more
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck. Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial…
Linsui Deng, Kejun He, Xianyang Zhang
Mendelian randomization (MR) has been widely used to infer causal relationships between exposures and outcomes in epidemiological studies. However, classical MR assumptions can be violated when genetic variants are associated with outcomes through pathways other than the exposure, leading to uncorrelated and/or…
Eliezer Masliah
How transient neural representations become integrated and stable enough to function as internal neural models remains incompletely understood. Grounded in efficient coding, Bayesian and predictive frameworks, recurrent and attractor dynamics, neural state-space models, and systems neuroscience, the Principle of…
Jama Mohamed, Hamse Mohamed Amoud, Ahmed Ismail Mohamed, Abdisalam Hassan Muse + 2 more
2.3.1#### Dependent Variable In this study, the dependent variable is the number of TT injections received before giving birth (i.e., 0, 1, 2, …, 8). 2.3.2#### Independent Variables To achieve the study's objective, we selected 25 variables that may influence the number of TT vaccine injections received before birth.…