12 papers · ranked by Valyu relevance
Jaime Carrasco, Fulgencio Lisón, Andrés Weintraub
Traditional Species Distribution Models (SDMs) may not be appropriate when examples of one class (e.g. absence or pseudo-absences) greatly outnumber examples of the other class (e.g. presences or observations), because they tend to favor the learning of observations more frequently. We present an ensemble method called…
Hannah Klinkhammer, Christian Staerk, Carlo Maj, Peter M. Krawitz + 1 more
Polygenic risk scores (PRS) evaluate the individual genetic liability to a certain trait and are expected to play an increasingly important role in the field of clinical risk stratification. Most often, PRS are estimated based on summary statistics of univariate effects derived from genome-wide association studies. To…
Xiaoye Mo, Xia Jiang
Ubiquitination-site prediction is an important task because ubiquitination is a critical regulatory function for many biological processes such as proteasome degradation, DNA repair and transcription, signal transduction, endocytoses, and sorting. However, the highly dynamic and reversible nature of ubiquitination…
Tomohiro Ishibashi, Akio Onogi
Mapping quantitative trait loci (QTLs) is one of the major goals of quantitative genetics; however, identifying the interactions between QTLs remains challenging. Recently developed machine learning methods, such as deep learning and gradient boosting, are transforming the real world. These methods could advance QTL…
David Enoma, Victor Chukwudi Osamor, Ogunlana Olubanke
Genome-wide association studies (GWAS) identify the variants (Single Nucleotide polymorphisms) associated with a disease phenotype within populations. These genetic differences are essential in variations in incidence and mortalities, especially for Prostate cancer in the African population. Given the complexity of…
Jorge Luís Machado do Amaral, Cíntia Moraes de Sá Sousa, Caroline de Oliveira Ribeiro, Paula Morisco de Sá + 2 more
Silicosis, the most dangerous and common lung illness associated with breathing in mineral dust, is a significant health concern. Spirometry, the traditional method for evaluating pulmonary functions, requires high patient compliance. Respiratory Oscillometry and electrical models are being studied to evaluate the…
Dániel Sándor, Péter Antal
In multitask federated learning, when small amounts of data are available, it can be harder to achieve proper predictive performance, especially if the clients’ tasks are different. However, task heterogeneity is common in modern Drug-Target interaction (DTI) prediction problems. As the data available for DTI tasks are…
Joshua P. Kulasingham, Jonathan Z. Simon
The Temporal Response Function (TRF) is a linear model of neural activity time-locked to continuous stimuli, including continuous speech. TRFs based on speech envelopes typically have distinct components that have provided remarkable insights into the cortical processing of speech. However, current methods may lead to…
Sayyed Jalil Mahdizadeh, Leif A. Eriksson
In the quest for accelerating de novo drug discovery, the development of efficient and accurate scoring functions represents a fundamental challenge. This study introduces iScore, a novel machine learning (ML)-based scoring function designed to predict the binding affinity of protein-ligand complexes with remarkable…
Amirhossein Modabbernia, Heather C. Whalley, David C. Glahn, Paul M. Thompson + 2 more
Application of machine learning algorithms to structural magnetic resonance imaging (sMRI) data has yielded behaviorally meaningful estimates of the biological age of the brain (brain-age). The choice of the machine learning approach in estimating brain-age in children and adolescents is important because age-related…
William Manley, Tam Tran, Melissa Prusinski, Dustin Brisson
General linear models have been the foundational statistical framework used to discover the ecological processes that explain the distribution and abundance of natural populations. Analyses of the rapidly expanding cache of environmental and ecological data, however, require advanced statistical methods to contend with…
Björn-Hergen Laabs von Holt, Ana Westenberger, Inke R. König
In life sciences random forests are often used to train predictive models. However, gaining any explanatory insight into the mechanics leading to a specific outcome is rather complex, which impedes the implementation of random forests into clinical practice. By simplifying a complex ensemble of decision trees to a…