23 papers · ranked by Valyu relevance
Yuta Soga, Kazutaka Maeda, Shiro Egawa, Enrique Contreras-Hernandez + 5 more
Proprioceptive signals from primary afferents reflect changes in single-joint angles, whereas neuronal population in the cerebral cortex represent whole-limb postures. Where and how this transformation emerges along the somatosensory axis from peripheral proprioceptive receptors remains unclear. We simultaneously…
Bing Han, Chushu Zhou, Yifan Yang, Wei Wang + 3 more
Bootstrap-based Self-Supervised Learning (SSL) has achieved remarkable progress in audio understanding. However, existing methods typically operate at a single level of granularity, limiting their ability to model the diverse temporal and spectral structures inherent in complex audio signals. Furthermore, bootstrapping…
Salman L. Butt, Ruchi Rani, Mohammed Nooruzzaman, Elena A. Demeter + 3 more
The spillover of highly pathogenic avian influenza (HPAI) A H5N1 virus to mammalian hosts raises major concerns due to its pandemic potential. Cats are frequently affected mammals, often succumbing to systemic and neurological disease. Here, we characterized the pathogenesis and transmissibility of two H5N1 genotypes…
Authors not listed
The Golgi apparatus (GA) orchestrates protein modification, trafficking, and secretion through highly dynamic remodeling, yet its proteomic complexity remains difficult to resolve in living systems. Here, we report CAT-Golgi, a genetically independent and light-controlled photocatalytic proximity labeling strategy for…
Yiyao Liua, Wenxiao He, Liyuan Ren, Huan Wang
Metal surface defect detection is critical for maintaining product quality in industrial manufacturing. However, it faces significant challenges, including limited annotated data, difficulty in identifying subtle multi-scale defects, and poor generalization across diverse scenarios. To address these issues, this paper…
Chunxi Tu, Jiatao Wu, Zeguang Huang, Jiaxing Xie + 1 more
Title: Simple Summary Cats show changes in health, stress, and welfare through everyday behavior, but recognizing these behaviors from ordinary video is not easy. In real-world recordings, cats bend and twist, and important clues from the head and tail may be blurred, partly hidden, or briefly lost. In this study, we…
Kiki E. Spoelstra, Jennifer Vonk, Evy van Berlo, José Kok + 2 more
Background Successful interpretation of emotion expressions is a critical aspect of communication in both solitary and group-living species, although it is seldom investigated in the former. Because of their flexible sociality, domestic cats (Felis silvestris*catus*) are an interesting species within which to study…
Kate Dutton-Regester, Jacquie Rand, Vanessa Rohlf, Pauleen Bennett + 2 more
Title: Simple Summary Cats have lived on Australian dairy farms for generations, where farmers often value them for helping control rodents and for companionship. However, when cat populations are unmanaged, problems can arise, including poor welfare, disease risks, environmental impacts, and distress for farmers who…
Hannah E. Urig, Kimberly A. Woodruff, W. Cooper Brookshire, David R. Smith
This study aimed to determine the true prevalence of feline leukemia virus (FeLV) infections in apparently healthy and sick shelter cats in Mississippi and estimate the predictive value of a lateral flow test results at the estimated true prevalences to guide testing recommendations. Blood samples (n = 383) were…
Giulia Russo, Carmen Borrelli, Karen L. Overall, Chiara Mariti + 1 more
Title: Simple Summary Cats are increasingly involved in animal-assisted services (AAS), making it important to ensure their welfare during these activities. However, using a systematic search, we found that no studies specifically address how to monitor cat welfare in this context. Therefore, we performed a new search…
Jonah Weigand-Whittier, Samuel Rubin, Cindy Ayala, Mark Velasquez + 5 more
Purpose: As interest in CEST-MRI grows, particularly in the preclinical setting, the necessity for standardized and easy-to-use acquisition and data analysis pipelines has become apparent. While vendors have increasingly introduced support for CEST acquisitions on both clinical and preclinical hardware, image…
Yvan Rousset, Alexander Kroll, Martin J. Lercher
Accurately predicting enzyme turnover rates (k_cat_) for variant enzymes is essential for understanding the functional consequences of genetic variation and for rational protein engineering, as experimental determination remains challenging. Current computational methods offer general models that predict k_cat_ across…
Liu, Xiaoyu, Zhang, Fuwei + 14 more
Generative retrieval (GR) has gained significant attention as an effective paradigm that integrates the capabilities of large language models (LLMs). It generally consists of two stages: constructing discrete semantic identifiers (IDs) for documents and retrieving documents by autoregressively generating ID tokens. The…
Authors not listed
A framework for catalysis based on categorical aperture selection rather than temporal acceleration is presented. Traditional catalysis theory describes catalysts as agents that accelerate reactions by lowering activation energies, implicitly treating time as the fundamental variable and reaction rate enhancement as…
Daniel Puthawala, Brendan Reardon, Lawrence Babb, Kori Kuzma + 10 more
Categorical variants, or sets of genomic alterations constrained by shared properties, are pervasive across clinical, regulatory, and research domains in the biomedical ecosystem, yet their inconsistent and non-computable representation hinders data interoperability and clinical interpretation. We surveyed genomic…
Shah, Arya, Tripathi, Vaibhav
Cats and humans differ in ocular anatomy. Most notably, Felis Catus (domestic cats) have vertically elongated pupils linked to ambush predation; yet, how such specializations manifest in downstream visual representations remains incompletely understood. We present a unified, frozen-encoder benchmark that quantifies…
Authors not listed
The automated discovery of chemical and catalytic reactions remains a major challenge in computational chemistry, particularly in complex systems where conventional methods struggle to identify optimal searching directions. Here, we propose Loxodynamics, a machine-learning-driven approach for reaction exploration via…
Authors not listed
Using light energy to drive chemical transformations is of great relevance, with nature’s photosynthesis as grand example. In artificial light-driven catalysis, part of nature’s complex supramolecular architecture is mimicked through so-called covalently linked photosensitizer-catalyst (PS-CAT) dyads. We herein report…
Christopher Miller, Daniel Lum, Brandon Rodenburg, Michael Stenner + 3 more
The volume of clear-air turbulence (CAT) in the atmosphere at flight cruising altitudes is increasing rapidly, posing a growing problem for civil aviation and resulting in reduced confidence in aviation safety. There are limited remote detection capabilities for CAT, since clear air produces no measurable radar return.…
Jonah Weigand-Whittier, Samuel Rubin, Cindy Ayala, Mark Velasquez + 5 more
2.1### Overview and layout Pre-CAT was developed in Python using Streamlit, an open-source framework for designing and sharing interactive data applications. As such, Pre-CAT can be deployed using several different methods. First, Pre-CAT can be run directly from the source code (available on GitHub) for local data…
Kyungsoo Ha, Soo-Young Yum, Hyeji Kwon, Ho Won Lee + 4 more
Allergic responses to the major cat allergen Fel d 1 are primarily driven by immunoglobulin E (IgE) cross-linking on effector cells. While conventional allergen-specific immunotherapies often rely on whole-allergen extracts with inherent risks of systemic reactions, rationally engineered variants offer a safer path to…
Ganma Tanaka, Rikuto Goto, Tetsushi Komoto, Akiko Kubota + 4 more
Crandell-Rees Feline Kidney (CRFK; kidney-derived) cells and PG-4 cells (astrocyte-derived) have been in use and have been passaged for decades in laboratories worldwide; however, no detailed information on the genetic background of the donor individuals is available, particularly regarding phenotype characteristics…
Edwina Gildea, Jill Thompson, Alasdair Cook, George Skingley + 5 more
Introduction Osteoarthritis (OA) in cats causes pain and mobility impairment, negatively impacting quality of life (QoL) of cats and their owners. Owner-perceived treatment satisfaction can influence treatment adherence and subsequent health outcomes for the cat. Currently, no OA-specific instrument for cats assesses…