16 papers · ranked by Valyu relevance
Muffy Calder, Claire Craig, Dave Culley, Richard de Cani + 15 more
'Christl A. Donnelly' 'Rowan Douglas' 'Bruce Edmonds' 'Jonathon Gascoigne' 'Nigel Gilbert' 'Caroline Hargrove' 'Derwen Hinds' 'David C. Lane' 'Dervilla Mitchell' 'Giles Pavey' 'David Robertson' 'Bridget Rosewell' 'Spencer Sherwin' 'Mark Walport' 'Alan Wilson'] In order to deal with an increasingly complex world, we…
Axel Loewe, Peter J. Hunter, Peter Kohl
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of ‘reductionism and integrationism’ seems less controversial today, a new…
Jacek A Kopec, Philippe Finès, Douglas G Manuel, David L Buckeridge + 9 more
Background Computer simulation models are used increasingly to support public health research and policy, but questions about their quality persist. The purpose of this article is to review the principles and methods for validation of population-based disease simulation models. Methods We developed a comprehensive…
N. El Faquir, B. Ren, N. M. Van Mieghem, J. Bosmans + 1 more
'P. P. de Jaegere'] Transcatheter aortic valve implantation is increasingly used to treat patients with severe aortic stenosis who are at increased risk for surgical aortic valve replacement and is projected to be the preferred treatment modality. As patient selection and operator experience have improved, it is…
Mark R. Davies, Ken Wang, Gary R. Mirams, Antonello Caruso + 6 more
'Denis Noble' 'Antje Walz' 'Thierry Lavé' 'Franz Schuler' 'Thomas Singer' 'Liudmila Polonchuk'] Title: Highlights 1. • Modelling and simulation can streamline decision making in drug safety testing. 2. • Computational cardiac electrophysiology is a mature technology with a long heritage. 3. • There are many challenges…
Konrad Hinsen
Computational techniques have revolutionized many aspects of scientific research over the last few decades. Experimentalists use computation for data analysis, processing ever bigger data sets. Theoreticians compute predictions from ever more complex models. However, traditional articles do not permit the publication…
N. Furian, M. O’Sullivan, C. Walker, S. Vössner + 1 more
Conceptual Modeling (CM) is a fundamental step in a simulation project. Nevertheless, it is only recently that structured approaches towards the definition and formulation of conceptual models have gained importance in the Discrete Event Simulation (DES) community. As a consequence, frameworks and guidelines for…
Panagiotis D. Kolokathis, Nikolaos K. Sidiropoulos, Dimitrios Zouraris, Dimitra-Danai Varsou + 20 more
Modelling Data (MODA) reporting guidelines have been proposed for common terminology and for recording metadata for physics-based materials modelling and simulations in a CEN Workshop Agreement (CWA 17284:2018). Their purpose is similar to that of the Quantitative Structure-Activity Relationship (QSAR) model report…
Syed Mohiuddin, John Busby, Jelena Savović, Alison Richards + 4 more
'Kate Northstone' 'William Hollingworth' 'Jenny L Donovan' 'Christos Vasilakis'] Objectives Overcrowding in the emergency department (ED) is common in the UK as in other countries worldwide. Computer simulation is one approach used for understanding the causes of ED overcrowding and assessing the likely impact of…
Szymon Wasik, Tomasz Prejzendanc, Jacek Blazewicz
Computational modeling is an important element of systems biology. One of its important applications is modeling complex, dynamical, and biological systems, including viral infections. This type of modeling usually requires close cooperation between biologists and mathematicians. However, such cooperation often faces…
Lesley A. Ogilvie, Aleksandra Kovachev, Christoph Wierling, Bodo M. H. Lange + 1 more
'Bodo M. H. Lange' 'Hans Lehrach'] Every patient and every disease is different. Each patient therefore requires a personalized treatment approach. For technical reasons, a personalized approach is feasible for treatment strategies such as surgery, but not for drug-based therapy or drug development. The development of…
Janina Wellmann
Over the course of the last three decades, computer simulations have become a major tool of doing science and engaging with the world, not least in an effort to predict and intervene in a future to come. Born in the context of the Second World War and the discipline of physics, simulations have long spread into most…
Niloofar Shahidi, Michael Pan, Soroush Safaei, Kenneth Tran + 3 more
'Edmund J. Crampin' 'David P. Nickerson' 'Daniel A. Beard'] Simulating complex biological and physiological systems and predicting their behaviours under different conditions remains challenging. Breaking systems into smaller and more manageable modules can address this challenge, assisting both model development and…
Richard M. Wood, Simon J. Moss, Ben J. Murch, Christos Vasilakis + 1 more
'Philip L. Clatworthy'] Background Optimising capacity along clinical pathways is essential to avoid severe hospital pressure and help ensure best patient outcomes and financial sustainability. Yet, typical approaches, using only average arrival rate and average lengths of stay, are known to underestimate the number of…
Anja Bethge, Udo Schumacher, Andreas Wree, Gero Wedemann + 1 more
Background Metastasis formation remains an enigmatic process and one of the main questions recently asked is whether metastases are able to generate further metastases. Different models have been proposed to answer this question; however, their clinical significance remains unclear. Therefore a computer model was…
Pupung Purnamasari, Noor Afza Amran, Rudy Hartanto
Background: This study aims to examine public sector auditors' tendency to use somputer assisted audit techniques (CAATs) in managing their audit works. Methods: A total of 400 questionnaires were distributed to auditors working in the public sectors in Central Java, West Java, and East Java. From the total, 225…