15 papers · ranked by Valyu relevance
Axel Loewe, Peter J. Hunter, Peter Kohl
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of ‘reductionism and integrationism’ seems less controversial today, a new…
Sara Bridio, Pierre Deceuninck, Maurice Whelan, Andrew Worth
Computational medicine promises significant advancements in healthcare, using physics-based simulations and artificial intelligence to optimise disease diagnosis, personalise treatment strategies and accelerate medical innovation. Biomedical research efforts are generating a growing number of computational models of…
Catherine Bjerre Collin, Tom Gebhardt, Martin Golebiewski, Tugce Karaderi + 7 more
'Tugce Karaderi' 'Maximilian Hillemanns' 'Faiz Muhammad Khan' 'Ali Salehzadeh-Yazdi' 'Marc Kirschner' 'Sylvia Krobitsch' '' 'Lars Kuepfer' 'William J. Duddy'] The future development of personalized medicine depends on a vast exchange of data from different sources, as well as harmonized integrative analysis of…
Marcello Pompa, Simona Panunzi, Alessandro Borri, Laura D’Orsi + 2 more
Large volumes of data are these days collected and archived from patients in a variety of clinical settings. This phenomenon is the product of the evolution of analysis systems and the appearance of new diagnostic techniques . The physician has thus in many cases observations of the clinical status of the patient at…
Jonathan Karr, Rahuman S. Malik-Sheriff, James Osborne, Gilberto Gonzalez-Parra + 14 more
'Gilberto Gonzalez-Parra' 'Eric Forgoston' 'Ruth Bowness' 'Yaling Liu' 'Robin Thompson' 'Winston Garira' 'Jacob Barhak' 'John Rice' 'Marcella Torres' 'Hana M. Dobrovolny' 'Tingting Tang' 'William Waites' 'James A. Glazier' 'James R. Faeder' 'Alexander Kulesza'] During the COVID-19 pandemic, mathematical modeling of…
Ester Comellas, Sandra J. Shefelbine
Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the stages of model…
John M. Drake
Modelling has become a routine part of ecological and evolutionary research, yet its practice often lacks a clear conceptual framework. I propose that modelling can be fruitfully understood as experimentation. Like empirical studies, modelling projects involve treatments, levels and responses: parameter regimes or data…
Louise M. Kimpton, L. Mihaela Paun, Mitchel J. Colebank, Victoria Volodina
'Victoria Volodina'] Uncertainty quantification (UQ) is an essential aspect of computational modelling and statistical prediction. Multiple applications, including geophysics, climate science and aerospace engineering, incorporate UQ in the development and translation of new technologies. In contrast, the application…
Panagiotis D. Kolokathis, Nikolaos K. Sidiropoulos, Dimitrios Zouraris, Dimitra-Danai Varsou + 20 more
Modelling Data (MODA) reporting guidelines have been proposed for common terminology and for recording metadata for physics-based materials modelling and simulations in a CEN Workshop Agreement (CWA 17284:2018). Their purpose is similar to that of the Quantitative Structure-Activity Relationship (QSAR) model report…
Philip Greulich
Purpose of Review This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ them to boost stem cell research, by helping to answer biological questions and to predict the outcome of biological processes. Recent Findings The twenty-first century has seen a…
Franziska Taeger, Lena Mende, Steffen Fleßa
Different types of mathematical models can be used to forecast the development of diseases as well as associated costs and analyse the cost-effectiveness of interventions. The set of models available to assess these parameters, reach from simple independent equations to highly complex agent-based simulations. For many…
Steffen Zschaler, Navonil Mustafee, Alison Harper, Thomas Monks + 3 more
Simulation remains a promising technology in healthcare operations research and process optimisation. However, while there have been many research projects applying simulation in this context, the level of sustained uptake in healthcare practice has been lower. We conjecture that an important reason for this is the…
Gilbert Greefrath, Hans-Stefan Siller, Katrin Vorhölter, Gabriele Kaiser
Discrete mathematics and mathematical modelling, along with the educational discourse surrounding these, have many connections. However, ways that the educational discourse on discrete mathematics can benefit from the inclusion of examples of mathematical modelling and the accompanying discussion are currently…
Pupung Purnamasari, Noor Afza Amran, Rudy Hartanto
Background: This study aims to examine public sector auditors' tendency to use somputer assisted audit techniques (CAATs) in managing their audit works. Methods: A total of 400 questionnaires were distributed to auditors working in the public sectors in Central Java, West Java, and East Java. From the total, 225…
Mario Martini, Carolin Kemper
Gehirn-Computer-Schnittstellen beflügeln die Hoffnung auf übermenschliche Kräfte: Sie versetzen Nutzer in die Lage, Prothesen und sonstige Geräte allein mit ihren Gedanken zu steuern. Je weiter die Entwicklung der neuen Technologie voranschreitet und in marktfähige Produkte mündet, desto sichtbarer rücken auch…