4 papers · ranked by Valyu relevance
Swarup Subudhi, Ghansham Chandel, Vishal Sivasankar, Siddhartha Das
Magnetic nanoparticles (MNPs) have been extensively used for drug delivery, on-demand material deposition, etc. In this study, we demonstrate the capability to extract MNPs on-demand from a magnetic nanoparticle laden drop (MNLD) (i.e., a drop of stable aqueous dispersion of MNPs) suspended inside a highly viscous…
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The rise of antibiotic resistance has necessitated the exploration of unconventional sources for novel antimicrobial agents. One emerging novel frontier is "de-extinct" molecules – bioactive peptides, antibiotics, and other bioactive agents reconstructed from ancient or extinct organisms – a groundbreaking convergence…
Wout Bittremieux, Varun Ananth, William E. Fondrie, Carlo Melendez + 5 more
Protein tandem mass spectrometry data is most often interpreted by matching observed mass spectra to a protein database derived from the reference genome of the sample being analyzed. In many application domains, however, a relevant protein database is unavailable or incomplete, and in such settings de novo sequencing…
Diana L. Prado-Romero, Fernanda I. Saldívar-González, Iván López-Mata, Pedro A. Laurel-García + 2 more
Designing and developing inhibitors against the epigenetic target DNA methyltransferase (DNMT) is an attractive strategy in epigenetic drug discovery. DNMT1 is one of the epigenetic enzymes with significant clinical relevance. Structure-based de novo design is a drug discovery strategy used in combination with…