12 papers · ranked by Valyu relevance
Jingcheng Zhang, Lei Chen, Jinlin Sun, Shumin Li + 5 more
DNA has emerged as a compelling archival storage medium, offering unprecedented information density and millennia-scale durability. Despite its promise, DNA-based data storage faces critical challenges due to error-prone processes during DNA synthesis, storage, and sequencing. In this study, we introduce Gungnir, a…
Alexandra Woolgar, Nadene Dermody, Soheil Afshar, Mark A. Williams + 1 more
Great excitement has surrounded our ability to decode task information from human brain activity patterns, reinforcing the dominant view of the brain as an information processor. We tested a fundamental but overlooked assumption: that such decodable information is actually used by the brain to generate cognition and…
John A. Hawkins, Stephen K. Jones, Ilya J. Finkelstein, William H. Press
Many large-scale high-throughput experiments use DNA barcodes—short DNA sequences prepended to DNA libraries—for identification of individuals in pooled biomolecule populations. However, DNA synthesis and sequencing errors confound the correct interpretation of observed barcodes and can lead to significant data loss or…
Zihui Yan, Guanjin Qu, Xin Chen, Gang Zheng + 1 more
DNA-based data storage is a promising solution to the challenges of large-scale data storage. However, the low throughput of the mainstream inkjet-based DNA synthesis method has hindered its widespread adoption. In contrast, high-throughput electrochemical synthesis provides higher throughput but with more nucleotide…
Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez + 18 more
Current storage technologies can no longer keep pace with exponentially growing amounts of data. ^1^ Synthetic DNA offers an attractive alternative due to its potential information density of ~ 10^18^ B/mm^3^, 10^7^ times denser than magnetic tape, and potential durability of thousands of years.^2^ Recent advances in…
Lifu Song, Feng Geng, Ziyi Gong, Bingzhi Li + 1 more
High density and long-term features make DNA data storage a potential media. However, DNA data channel is a unique channel with unavoidable ‘data reputations’ in the forms of multiple error-rich strand copies. This multi-copy feature cannot be well harnessed by available codec systems optimized for single-copy media.…
Shubham Chandak, Joachim Neu, Kedar Tatwawadi, Jay Mardia + 7 more
As magnetization and semiconductor based storage technologies approach their limits, bio-molecules, such as DNA, have been identified as promising media for future storage systems, due to their high storage density (petabytes/gram) and long-term durability (thousands of years). Furthermore, nanopore DNA sequencing…
Ian Holmes
We describe a strategy for constructing codes for DNA-based information storage by serial composition of weighted finite-state transducers. The resulting state machines can integrate correction of substitution errors; synchronization by interleaving watermark and periodic marker signals; conversion from binary to…
Kevin D. Volkel, Paul W. Hook, Albert Keung, Winston Timp + 1 more
As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and…
Yixin Wang, Md Noor-A-Rahim, Erry Gunawan, Yong Liang Guan + 1 more
Using DNA as the medium to store information has recently been recognized as a promising solution for long-term data storage. While several system prototypes have been demonstrated, the error characteristics in DNA data storage are discussed with limited content. Due to the data and process variations from experiment…
Andreas L. Gimpel, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
Efficient error-correction codes are crucial for realizing DNA’s potential as a long-lasting, high-density storage medium for digital data. At the same time, new workflows promising low-cost, resilient DNA data storage are challenging their design and error-correcting capabilities. This study characterizes the errors…
Inbal Preuss, Michael Rosenberg, Zohar Yakhini, Leon Anavy
With the world generating digital data at an exponential rate, DNA has emerged as a promising archival medium. It offers a more efficient and long-lasting digital storage solution due to its durability, physical density, and high information capacity. Research in the field includes the development of encoding schemes…