7 papers · ranked by Valyu relevance
Dianzhuo Wang, Qian Xu, Arjun Banerjee, Rishi Jain + 7 more
Inferring biological function from experimental data is central to understanding emerging pathogens and developing effective countermeasures, yet interpreting these data remains slow and expert-intensive. AI agents could help accelerate this process by reasoning across sequence, structural, and biophysical evidence. We…
William JF Rieger, Sebastian Häussermann, Luca Herrmann, Zecheng Li + 8 more
Enzymes frequently exhibit promiscuous activity beyond their native roles, providing starting-points for new functions. Finding these promiscuous enzymes, especially for non-native chemical transformations, is challenging but highly valuable, as they promise novel, sustainable solutions for chemistry and biotechnology.…
Xuebin Feng, Emma R. Master
Sequence similarity networks (SSNs) are graphical representations of sequence relationship frequently used for exploring protein sequence space. Conventional SSN workflows typically use BLAST to calculate sequence similarities and rely on external visualization tools to generate the final networks. Consequently, raw…
Yiming Xue, Xiaojian Liu, Weimin Zhu, Shengfan Wang + 2 more
While protein-RNA interactions are fundamental to post-transcriptional processes, achieving a holistic understanding of their regulatory logic remains challenging. Current computational models often treat binding affinity, interface mapping, and RNA design as isolated tasks, thereby failing to provide a unified…
Megan Sholomiski, Victor Yon, Franziska Mudlaff, Aparna Suvrathan
The cerebellum supports a wide range of motor and non-motor behaviors, yet the specific cerebellar regions and neuronal populations underlying this functional diversity remain poorly understood. Here, we mapped patterns of immediate early gene activation in the cerebellar cortex during the accelerating rotarod task, an…
Peter F. Pelz, Tobias Meck
For nearly a century, the physical origin of metabolic scaling has remained unresolved: metabolism is proportional to body mass in small organisms but follows Kleiber’s three-quarter-power law in larger animals. We derive both regimes from the Metabolic Holon (MH), a locally optimized capillary–tissue oxygen-supply…
ChenTianyi Yang, Andrew Thwaites, Cai Wingfield, Chao Zhang + 1 more
The brain builds meaning from speech in stages, transforming acoustic input into linguistic comprehension. Yet where comprehension separates from general acoustic processing has been difficult to localize, because the two are tightly entangled in continuous speech. Here we align the activity of 145,000 individual…