14 papers · ranked by Valyu relevance
Haripriya Vaidehi Narayanan, Alexander Hoffmann
Antibody-mediated adaptive immunity must provide effective long-term protection with minimal adverse effects, against rapidly mutating pathogens, in a human population with diverse ages, genetics, and immune histories. In order to grasp and leverage the complexities of the antibody response, we advocate for a…
Elisa Fleischmann, Vera Middelkamp, Theo van den Broek
Interactions between T- and B cells in the germinal center reaction are instrumental for the initiation, maintenance, and downregulation of the human adaptive immune response, leading to the production of antigen-specific antibodies and long-lasting immunological memory. Replicating the human immune system remains…
Bettina Budeus, Artur Kibler, Ralf Küppers
A hallmark of T cell dependent (TD) humoral immune responses is the generation of long-lived memory B cells. The generation of these cells occurs primarily in the germinal center (GC) reaction, where antigen-activated B cells undergo affinity maturation as a major consequence of the combined processes of proliferation…
Duncan K Ralph, Athanasios G Bakis, Jared Galloway, Ashni A Vora + 5 more
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GCs) from which mature B cells arise. It is known that B cells with higher affinity for their cognate antigen (Ag) will, on average, tend to…
Duncan K Ralph, Athanasios G Bakis, Jared G Galloway, Ashni A Vora + 7 more
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GCs) from which mature B cells arise. It is known that B cells with higher affinity for their cognate antigen (Ag) will, on average, tend to…
Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger + 1 more
'Brad G. Magor'] DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutator enzyme, Aicda. In fish there are clusters of…
Marta Cakala-Jakimowicz, Paulina Kolodziej-Wojnar, Monika Puzianowska-Kuznicka, Juan Pablo de Rivero Vaccari
'Monika Puzianowska-Kuznicka' 'Juan Pablo de Rivero Vaccari'] Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to…
Alana Kirn, Kim L. Good‐Jacobson
Memory B cells are essential for long-lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside. This review will discuss novel insights into the…
Damon L. Schmalzriedt, Erika R. Johansen, Carlie A. Aurubin, Cade R. Rahlf + 4 more
'Cade R. Rahlf' 'Bradey Stuart' 'Daisy Sahoo' 'Vera L. Tarakanova' 'Felicia Goodrum'] Title: ABSTRACT Lipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral…
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova + 1 more
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells. Additionally, infected germinal center B cells seed viral…
Amalie Grenov, Hadas Hezroni, Lior Lasman, Jacob H. Hanna + 1 more
'Ziv Shulman'] Title: Summary Antibody-mediated immunity is initiated by B cell differentiation into multiple cell subsets, including plasmablast, memory, and germinal center (GC) cells. B cell differentiation trajectories are determined by transcription factors, yet very few mechanisms that specifically determine…
Madiha Zahra Syeda, Tu Hong, Chunming Huang, Wenhua Huang + 1 more
Development of B cell memory is a conundrum that scientists are still exploring. Studies have been conducted in vitro and using advanced animal models to elucidate the mechanism underlying the generation of memory B cells (MBCs), the precise roles of MBCs against pathogens, and their protective functions against…
Linda M. Sircy, Andrew G. Ramstead, Lisa C. Gibbs, Hemant Joshi + 8 more
'Andrew Baessler' 'Ignacio Mena' 'Adolfo García-Sastre' 'Lyska L. Emerson' 'Keke C. Fairfax' 'Matthew A. Williams' 'J. Scott Hale' 'Zia Rahman'] Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious…
Linda M. Sircy, Andrew G. Ramstead, Hemant Joshi, Andrew Baessler + 4 more
'Ignacio Mena' 'Adolfo García-Sastre' 'Matthew A. Williams' 'J. Scott Hale'] Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center…