10 papers · ranked by Valyu relevance
R.G. Rebecca, Giorgio A. Ascoli, Nate M. Sutton, Holger Dannenberg
Spatial periodicity in grid cell firing has been interpreted as a neural metric for space providing animals with a coordinate system in navigating physical and mental spaces. However, the specific computational problem being solved by grid cells has remained elusive. Here, we provide mathematical proof that spatial…
Ben Sorscher, Gabriel C. Mel, Samuel A. Ocko, Lisa Giocomo + 1 more
The discovery of entorhinal grid cells has generated considerable interest in how and why hexagonal firing fields might mechanistically emerge in a generic manner from neural circuits, and what their computational significance might be. Here we forge an intimate link between the computational problem of…
Vemund Schøyen, Constantin Bechkov, Markus Borud Pettersen, Erik Hermansen + 4 more
The brain’s ability to navigate is often attributed to spatial cells in the hippocampus and entorhinal cortex. Grid cells, found in the entorhinal cortex, are known for their hexagonal spatial activity patterns and are traditionally believed to be the neural basis for path integration. However, recent studies have cast…
Dong Chen, Kai-Jia Sun, Liang Wang, Zhanjun Zhang + 3 more
Grid cells constitute a crucial component of the “GPS” in the mammalian brain. Recent experiments revealed that grid cell activity is anchored to environmental boundaries. More specifically, these results revealed a slight yet consistent offset of 8 degrees relative to boundaries of a square environment. The causes and…
Martin Stemmler, Alexander Mathis, Andreas V. M. Herz
Mammalian grid cells fire whenever an animal crosses the points of an imaginary, hexagonal grid tessellating the environment. Here, we show how animals can localize themselves and navigate by reading-out a simple population vector of grid cell activity across multiple scales, even though this activity is intrinsically…
Sangil Lee, Linda Q. Yu, Caryn Lerman, Joseph W. Kable
Across many studies, ventromedial prefrontal cortex (vmPFC) activity has been found to correlate with subjective value during value-based decision-making. Recently, however, vmPFC has also been shown to reflect a hexagonal gridlike code during navigation through physical and conceptual space. This raises the…
Bo Zhang, Jia Liu
The phenomenon of neuronal replay, the sequential reactivation of hippocampal place cells for past experiences, have been proposed to organize learned knowledges into a cognitive map. Here we used the spin-glass model to simulate the formation of the hexagonal pattern of grid cells, the metric of cognitive map, when…
Zhibing Xiao, Xiongfei Wang, Jinbo Zhang, Jianxin Ou + 5 more
Humans create internal cognitive maps that allow us to make inferences beyond direct experience. These maps often rely on hexagonal grid-cell-like neural codes, serving as a schema for two-dimensional (2D) spaces. Yet it remains unclear how new experiences become aligned with this schema, especially in non-spatial…
Mohammadreza Paraan, Joshua Mendez, Savanna Sharum, Danielle Kurtin + 2 more
Vesicle trafficking by clathrin coated vesicles (CCVs) is one of the major mechanisms by which proteins and nutrients are absorbed by the cell and transported between organelles. The individual proteins comprising the coated vesicles include clathrin heavy chain, clathrin light chain, and a variety of adaptor protein…
Man Yi Yim, Steven Walton, Kathryn Hedrick
In an open two-dimensional environment, grid cells in the medial entorhinal cortex are known to be active in multiple locations, displaying a striking periodic hexagonal firing pattern covering the entire space. Both modeling and experimental data suggest that such periodic spatial representations may emerge from a…