BbioRxiv8 Sep 2026
Early life stress alters lifespan trajectories of amygdala development: a cross-species model of amygdala burnout
M. Sheppard, J. Rasgado-Toledo, L.A. Trujillo Villarreal, M.C. Litwinczuk + 24 more
Early-life stress is associated with alterations in amygdala volume, but findings vary across studies and species. Rodent models typically report increased amygdala volume, whereas human studies often find reductions or mixed effects. We propose the amygdala burnout hypothesis, which suggests that early-life stress…