10 papers · ranked by Valyu relevance
Arne Kutzner, Pok-Son Kim, Markus Schmidt
Seeding is usually the initial step of high-throughput sequence aligners. Two popular seeding strategies are fixed-size seeding (k-mers, minimizers) and variable-size seeding (MEMs, SMEMs, max. spanning seeds). The former strategy benefits from fast index building and fast seed computation, while the latter one…
Virginia Delli, Charles-Antoine Seux, Julien Dehame, Sooraj Nair + 2 more
Gonadotropin-releasing hormone (GnRH) neurons are the final common target of a complex network of cells cooperating for the central control of reproduction. The balance between excitatory and inhibitory transsynaptic and non-synaptic inputs is crucial for the maintenance of the GnRH rhythms: the pulse and the surge.…
Serena R. Sweet, Jessica E. Biddinger, Jessie B. Zimmermann, Gina L. Yu + 1 more
Drinking and feeding are tightly coordinated homeostatic events and the paraventricular nucleus of the hypothalamus (PVH) represents a possible node of neural integration for signals related to energy and fluid homeostasis. We used TRAP2;Ai14 and Fos labeling to visualize neurons in the PVH and median preoptic nucleus…
Colton J. Lloyd, Ali Ebrahim, Laurence Yang, Zachary King + 4 more
Genome-scale models of metabolism and macromolecular expression (ME-models) explicitly compute the optimal proteome composition of a growing cell. ME-models expand upon the well-established genome-scale models of metabolism (M-models), and they enable new and exciting insights that are fundamental to understanding the…
Martín Gutiérrez, Yerko Ortiz, Javier Carrión
Metaheuristic procedures (MH) have been a trend driving Artificial Intelligence (AI) researchers for the past 50 years. A variety of tools and applications (not only in Computer Science) stem from these techniques. Also, MH frequently rely on evolution, a trademark process involved in cell colony growth. Generally, MH…
Paul Bello, Pedro Gallardo, Lorena Pradenas, Jacques A. Ferland + 1 more
Childhood obesity is an undeniable reality and has shown a rapid growth in many countries. Obesity at an early age not only increases the risks of chronic diseases but also produces a problem for the whole healthcare system. One way to alleviate this problem is to provide each patient with an appropriate menu that can…
Sergio Garcia, Cong Trinh
A large space of chemicals with broad industrial and consumer applications could be synthesized by engineered microbial biocatalysts. However, the current strain optimization process is prohibitively laborious and costly to produce one target chemical and often requires new engineering efforts to produce new molecules.…
Koichi Miyamoto, Naoki Yamamoto, Yasubumi Sakakibara
We propose two quantum algorithms for a problem in bioinformatics, position weight matrix (PWM) matching, which aims to find segments (sequence motifs) in a biological sequence such as DNA and protein that have high scores defined by the PWM and are thus of informational importance related to biological function. The…
Dogan Corus, Duc-Cuong Dang, Anton V. Eremeev, Per Kristian Lehre
Understanding how the time-complexity of evolutionary algorithms (EAs) depend on their parameter settings and characteristics of fitness landscapes is a fundamental problem in evolutionary computation. Most rigorous results were derived using a handful of key analytic techniques, including drift analysis. However…
Kim Bongsong
Suppose that members in a universal are categorized based on observations, and that categories can be stratified based on averages of observations within each category. Two sorting extremes can be obtained from the perspective of arbitrariness of an order of observations. The first sorting extreme is an increasing…