16 papers · ranked by Valyu relevance
Bruz Marzolf, Eric W Deutsch, Patrick Moss, David Campbell + 2 more
'Michael H Johnson' 'Timothy Galitski'] Background The biological information in genomic expression data can be understood, and computationally extracted, in the context of systems of interacting molecules. The automation of this information extraction requires high throughput management and analysis of genomic…
Allen Day, Marc RJ Carlson, Jun Dong, Brian D O'Connor + 1 more
'Stanley F Nelson'] Celsius is a new system that serves as a warehouse by aggregating Affymetrix files and associated metadata, and containing the largest publicly available source of Affymetrix microarray data.
Peijian Cao, Ki-Hong Jung, Daeseok Choi, Daehee Hwang + 2 more
'Pamela C Ronald'] Background Microarray technologies facilitate high-throughput gene expression analysis. However, the diversity of platforms for rice gene expression analysis hinders efficient analysis. Tools to broadly integrate microarray data from different platforms are needed. Results In this study, we developed…
Todd H Stokes, JT Torrance, Henry Li, May D Wang
Background A survey of microarray databases reveals that most of the repository contents and data models are heterogeneous (i.e., data obtained from different chip manufacturers), and that the repositories provide only basic biological keywords linking to PubMed. As a result, it is difficult to find datasets using…
Ming Zhang, Yudong Zhang, Li Liu, Lijuan Yu + 6 more
'Jing Tan' 'Wenhua Yao' 'Manjit S Kang' 'Yongqiang An' 'Xingming Fan'] Background In the last decade, a large amount of microarray gene expression data has been accumulated in public repositories. Integrating and analyzing high-throughput gene expression data have become key activities for exploring gene functions…
Lihua Ying, Minnie Sarwal
Microarray technologies have both fascinated and frustrated the transplant community since their introduction roughly a decade ago. Fascination arose from the possibility offered by the technology to gain a profound insight into the cellular response to immunogenic injury and the potential that this genomic signature…
Heather J. Ruskin, Massimo Negrini
High-throughput microarray technologies have long been a source of data for a wide range of biomedical investigations. Over the decades, variants have been developed and sophistication of measurements has improved, with generated data providing both valuable insight and considerable analytical challenge. The…
Miroslav Blumenberg
Recent years witnessed the birth of bioinformatics technologies, which greatly advanced biological research. These ‘omics’ technologies address comprehensively the entire genome, transcriptome, proteome, microbiome etc. A large impetus in development of bioinformatics was the introduction of DNA microarrays for…
Aristotelis Chatziioannou, Panagiotis Moulos, Fragiskos N Kolisis
Background The microarray data analysis realm is ever growing through the development of various tools, open source and commercial. However there is absence of predefined rational algorithmic analysis workflows or batch standardized processing to incorporate all steps, from raw data import up to the derivation of…
Yuerong Zhu, Yuelin Zhu, Wei Xu
Background Though microarray experiments are very popular in life science research, managing and analyzing microarray data are still challenging tasks for many biologists. Most microarray programs require users to have sophisticated knowledge of mathematics, statistics and computer skills for usage. With accumulating…
Markus Weniger, Julia C Engelmann, Jörg Schultz
Background Regulation of gene expression is relevant to many areas of biology and medicine, in the study of treatments, diseases, and developmental stages. Microarrays can be used to measure the expression level of thousands of mRNAs at the same time, allowing insight into or comparison of different cellular…
Greg Gibson
Microarrays can survey genome-wide expression patterns. Not only can these gene expression profiles be used to identify a few genes of interest, they are now being creatively applied for hypothesis generation and testing
Christian Schwager, Ute Wirkner, Amir Abdollahi, Peter E Huber
Background High-throughput "omics" based data analysis play emerging roles in life sciences and molecular diagnostics. This emphasizes the urgent need for user-friendly windows-based software interfaces that could process the diversity of large tab-delimited raw data files generated by these methods. Depending on the…
Pratik Jaluria, Konstantinos Konstantopoulos, Michael Betenbaugh, Joseph Shiloach
'Joseph Shiloach'] With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly being used in laboratories around the world. In fact, fields as varied as…
Yevhen Vainshtein, Mayka Sanchez, Alvis Brazma, Matthias W Hentze + 2 more
'Thomas Dandekar' 'Martina U Muckenthaler'] Background Gene expression studies greatly contribute to our understanding of complex relationships in gene regulatory networks. However, the complexity of array design, production and manipulations are limiting factors, affecting data quality. The use of customized DNA…
Argyris Tzouvelekis, George Patlakas, Demosthenes Bouros
Microarrays are a powerful tool that have multiple applications both in clinical and cell biology arenas of common lung diseases. To exemplify how this tool can be useful, in this review, we will provide an overview of the application of microarray technology in research relevant to common lung diseases and present…