6 papers · ranked by Valyu relevance
Li Peng, Weisi Lai, Jian Huang, Yan Zhong
Early detection of preeclampsia with noninvasive and reliable biomarkers is the foremost step for minimizing adverse effects during pregnancy. However, none maternal serum analyte evaluated so far is sufficiently accurate to allow recommending their routine use. Microarray was used to first identify differentially…
Lena Trnovec, Miha Štajdohar, Gad Shaulsky, Blaž Zupan
dictyExpress 3.0 is a React/TypeScript reimplementation of the Dictyostelium discoideum transcriptomics web server, first introduced in 2009, that unifies bulk and single-cell exploration. A long-standing gene-expression resource for the Dictyostelium community, dictyExpress is also accessible through dictyBase, the…
Shangru Jia, Artem Lysenko, Keith A Boroevich, Alok Sharma + 1 more
Prognostic stratification in multiple myeloma (MM) relies on staging systems fixed at diagnosis, discarding temporal information accumulated during treatment. We developed a dynamic multimodal framework that predicts residual overall survival from observation windows of 1-18 months post-diagnosis. The model integrates…
Xiaoyue Hu, Yuhao Ma, Ruixing Ming, Heping Zhang + 1 more
Identifying essential biomarkers remains a core challenge in elucidating the pathogenic mechanisms and achieving precise diagnosis of complex diseases. Deep neural networks offer immense predictive power, yet their lack of interpretability severely limits downstream biological insight. Here, we introduce DeepVaris, an…
Huihai Wu, Ashleigh Lister, Iain Macaulay, Katie Long + 10 more
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck. Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial…
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric + 7 more
Neoadjuvant chemoradiotherapy followed by total mesorectal excision is standard for locally advanced rectal cancer, but response varies and current markers are insufficient. This study integrates public bulk RNA-seq data to identify predictive features of response. TRIM54 and PABPC4 were upregulated in the responder…