5 papers · ranked by Valyu relevance
Jackie Rao, Muntadher Jihad, Giulia Biffi, Paul D.W. Kirk
Identifying cell types from single-cell RNA sequencing (scRNA-seq) data typically requires several separate and often uninterpretable steps: dimensionality reduction, batch-correction, clustering, marker-gene identification and the discovery of finer-grained structure. Here we introduce scFLAME (single-cell Factor…
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…
John Tower
Biological information is generally thought to be subject to selection for faithful maintenance. However, accurate preservation is often combined with regulated mechanisms that generate state change. Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives…
Manuel Treutlein, Pascal Bothe, Marc Schmidt, Roman Hahn + 4 more
The last mile of the distribution grid is crucial for a successful energy transition, as more low-carbon technology like photovoltaic systems, heat pumps, and electric vehicle chargers connect to the low-voltage grid. Despite considerable challenges in operation and planning, researchers often lack access to suitable…
James Stewart-Evans, Emma Wilson, Tessa Langley, Angela Hands + 2 more
Objective: The objective of this scoping review was to map the body of knowledge on net gain and no-net-loss (net-outcome) objectives and approaches applicable to health in spatial planning and development policies and practice. Introduction: There is an established body of academic and gray literature addressing…