17 papers · ranked by Valyu relevance
Daril E. Brown, Elizaveta V. Okorokova, Carrina Iacobacci, Brian Coughlin + 6 more
Neuropixels probes, initially developed for use in small animal models, have transformed basic neuroscience by enabling high-density, single-cell resolution recordings across multiple brain regions simultaneously. The recent development of Neuropixels 1.0 NHP Long—a longer probe designed for non-human primates—has…
Yi-Ting Chang, Rajan Dasgupta, Mingyuan Dong, Jennifer Colonell + 11 more
The brain orchestrates billions of neurons spanning hundreds of regions to drive behavior. High-density electrophysiology has provided insights into this process, but monitoring brain-wide patterns of spiking activity demands new tools. Here we present Neuropixels 2.0 Quad Base, a 1536-channel probe with four times the…
Zhiwen Ye, Andrew M. Shelton, Jordan R. Shaker, Julien Boussard + 29 more
To understand the neural basis of behavior, it is essential to sensitively and accurately measure neural activity at single neuron and single spike resolution. Extracellular electrophysiology delivers this, but it has biases in the neurons it detects and it imperfectly resolves their action potentials. To minimize…
Hyeyoung Shin, Mora B. Ogando, Lamiae Abdeladim, Uday K. Jagadisan + 23 more
When sensory information is incomplete, the brain relies on prior expectations to infer perceptual objects. Despite the centrality of this process to perception, the neural mechanisms of sensory inference are not understood. Here we used illusory contours (ICs), multi-Neuropixels measurements, mesoscale two-photon (2p)…
Eric M. Trautmann, Janis K. Hesse, Gabriel M. Stine, Ruobing Xia + 24 more
'Shude Zhu' 'Daniel J. O’Shea' 'Bill Karsh' 'Jennifer Colonell' 'Frank F. Lanfranchi' 'Saurabh Vyas' 'Andrew Zimnik' 'Elom Amematsro' 'Natalie A. Steinemann' 'Daniel A. Wagenaar' 'Marius Pachitariu' 'Alexandru Andrei' 'Carolina Mora Lopez' 'John O’Callaghan' 'Jan Putzeys' 'Bogdan C. Raducanu' 'Marleen Welkenhuysen'…
Anna Lakunina, Karolina Z Socha, Alexander Ladd, Anna J Bowen + 25 more
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations, and is especially powerful when combined with optogenetics for manipulation of specific cell types with high temporal resolution. We integrated these approaches into prototype Neuropixels Opto…
Eric M. Trautmann, Janis K. Hesse, Gabriel M. Stine, Ruobing Xia + 22 more
High-density, integrated silicon electrodes have begun to transform systems neuroscience, by enabling large-scale neural population recordings with single cell resolution. Existing technologies, however, have provided limited functionality in nonhuman primate species such as macaques, which offer close models of human…
Anna A. Lakunina, Karolina Z. Socha, Alexander E. Ladd, Anna J. Bowen + 25 more
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations and is especially powerful when combined with optogenetics for manipulation of specific cell types with high temporal resolution. We integrated these approaches into prototype Neuropixels Opto…
Anne E. Urai, Brent Doiron, Andrew M. Leifer, Anne K. Churchland
Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. Here, we first describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to…
Leslie D Claar, Irene Rembado, Jacqulyn R Kuyat, Simone Russo + 5 more
'Lydia C Marks' 'Shawn R Olsen' 'Christof Koch' 'Michael B Eisen' 'Michael B Eisen'] Perturbational complexity analysis predicts the presence of consciousness in volunteers and patients by stimulating the brain with brief pulses, recording EEG responses, and computing their spatiotemporal complexity. We examined the…
Antoine Ghestem, Marco N Pompili, Matthias Dipper-Wawra, Pascale P Quilichini + 2 more
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these electrodes is in acute preparations, some scientific inquiries require long-term recordings in freely moving animals. Recent reports have presented prosthesis designs for chronic…
Arnau Marin-Llobet, Richard Hakim, Sara Matias, Venkatesh N. Murthy + 2 more
Identifying what individual neurons encode in higher-order visual cortex is an open problem. Responses resist intuitive parameterization, and the deep-network embeddings used in their place are black boxes. Here, we introduce NEURRATOR, a framework that decodes spiking activity into free-form natural-language narration…
Zeinab Mohammadi, Daniel J Denman, Achim Klug, Tim C Lei
Objective: The sorting of neural spike data recorded by multichannel and high channel neural probes such as Neuropixels, especially in real-time, remains a significant technical challenge. Most neural spike sorting algorithms focus on sorting neural spikes post-hoc for high sorting accuracy-but reducing the processing…
Ji Xia, Yizi Zhang, Shuqi Wang, Genevera I. Allen + 3 more
Characterizing interactions between brain areas is a fundamental goal of systems neuroscience. While such analyses are possible when areas are recorded simultaneously, it is rare to observe all combinations of areas of interest within a single animal or recording session. How can we leverage multi-animal datasets to…
Alexandra N. Busch, Roberto C Budzinski, Federico W. Pasini, Ján Mináč + 7 more
'Ján Mináč' 'Jonathan Michaels' 'Megan Roussy' 'Rossella Gulli' 'B Corrigan' 'J. Andrew Pruszynski' 'Julio Martinez‐Trujillo' 'Lyle Muller'] Recent advances in neural recording technology allow simultaneously recording action potentials from hundreds to thousands of neurons in awake, behaving animals. However…
Saskia EJ de Vries, Joshua H Siegle, Christof Koch, Markus Meister + 1 more
Nullius in verba (‘trust no one’), chosen as the motto of the Royal Society in 1660, implies that independently verifiable observations-rather than authoritative claims-are a defining feature of empirical science. As the complexity of modern scientific instrumentation has made exact replications prohibitive, sharing…
Carsen Stringer, Lin Zhong, Atika Syeda, Fengtong Du + 1 more
Neurophysiology has long progressed through exploratory experiments and chance discoveries. Anecdotes abound of researchers setting up experiments while listening to spikes in real time and observing a pattern of consistent firing when certain stimuli or behaviors happened. With the advent of large-scale recordings…