17 papers · ranked by Valyu relevance
Jasdeep Kaur Dhanoa, Ram Saran Sethi, Ramneek Verma, Jaspreet Singh Arora + 1 more
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2-3% of the genomic DNA is transcribed to protein-coding mRNA. Interestingly, only a further minuscule part of genomic DNA encodes for long non-coding RNAs (lncRNAs) which are characteristically…
Victoria E. Villegas, Peter G. Zaphiropoulos, Martin Pichler
Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of…
Carl Ernst, Cynthia C. Morton
Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs. Recent studies of lncRNAs across different species have revealed a diverse…
Elena López-Jiménez, Eduardo Andrés-León, Michael Janitz
The mammalian genome comprehends a small minority of genes that encode for proteins (barely 2% of the total genome in humans) and an immense majority of genes that are transcribed into RNA but not encoded for proteins (ncRNAs). These non-coding genes are intimately related to the expression regulation of protein-coding…
Roman Beňačka, Daniela Szabóová, Zuzana Guľašová, Zdenka Hertelyová + 3 more
Non-coding RNAs (ncRNAs) are abundant single-stranded RNA molecules in human cells, involved in various cellular processes ranging from DNA replication and mRNA translation regulation to genome stability defense. MicroRNAs are multifunctional ncRNA molecules of 18-24 nt in length, involved in gene silencing through…
Laura Poliseno, Martina Lanza, Pier Paolo Pandolfi
The advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs that are seemingly not translated into proteins. It was also found that non-coding RNA transcripts outnumber canonical protein-coding genes. This mindboggling discovery prompted a surge in non-coding RNA research…
William A. Haseltine, Roberto Patarca, Alfonso Baldi
Human genome projects in the 1990s identified about 20,000 protein-coding sequences. We are now in the RNA revolution, propelled by the realization that genes determine phenotype beyond the foundational central molecular biology dogma, stating that inherited linear pieces of DNA are transcribed to RNAs and translated…
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz
Noncoding RNAs (ncRNAs) are a diverse and abundant class of molecules that play essential roles in gene regulation across eukaryotic organisms, including roles in human homeostasis and disease. Historically regarded as transcriptional artifacts or byproducts, ncRNAs are now recognized as essential regulators of…
Éva Márton, Alexandra Varga, Dóra Domoszlai, Gergely Buglyó + 9 more
'Anita Balázs' 'András Penyige' 'István Balogh' 'Bálint Nagy' 'Melinda Szilágyi' 'Charles H. Lawrie' 'Margarete Odenthal' 'Sanjay Premi' 'Jyoti Srivastava'] Title: Simple Summary The field of non-coding RNAs has growing interest in cancer research since these molecules play a prominent role in the regulation of cancer…
Chunyu Wang, Leyi Wei, Maozu Guo, Quan Zou
The important role of non coding RNAs (ncRNAs) in the cell has made their identification a critical issue in the biological research. However, traditional approaches such as PT-PCR and Northern Blot are costly. With recent progress in bioinformatics and computational prediction technology, the discovery of ncRNAs has…
Daniel Frías-Lasserre
The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and genes. ncRNAs are also becoming central for understanding gene…
Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Muhammad Imran Malik, Andreas Dengel + 2 more
Apart from protein-coding Ribonucleic acids (RNAs), there exists a variety of non-coding RNAs (ncRNAs) which regulate complex cellular and molecular processes. High-throughput sequencing technologies and bioinformatics approaches have largely promoted the exploration of ncRNAs which revealed their crucial roles in gene…
Amil Shah, Vincenzo Zappavigna
The discovery of oncogenes and tumor suppressor genes provided important insights into the molecular pathogenesis of cancer but also revealed some contradictions in the prevailing somatic mutation theory. The evidence that noncoding RNAs (ncRNAs) form an elaborate network that regulates the flow of genetic information…
Florent Hubé, Claire Francastel
The first non-coding RNA ever identified was the alanine (Ala) transfer RNA (tRNA), purified from yeast, whose structure was published in 1965 (Holley et al., ). This Ala-tRNA, like the other tRNAs, is involved in protein synthesis by carrying the amino acid Ala to the protein chain being synthesized. Since this…
Armen R. Karapetyan, Coen Buiting, Renske A. Kuiper, Marcel W. Coolen
'Marcel W. Coolen'] Recent advances in high-throughput sequencing technology have identified the transcription of a much larger portion of the genome than previously anticipated. Especially in the context of cancer it has become clear that aberrant transcription of both protein-coding and long non-coding RNAs (lncRNAs)…
Sebastian Marquardt, Pablo Andrés Manavella
The idea of ‘information flow’, which describes how DNA is decoded into proteins using an intermediary called mRNA, is at the core of molecular biology and a well-known concept throughout education. However, there is a big pool of cellular RNAs that are functional but do not encode proteins. Thanks to the development…
Romana Butova, Petra Vychytilova-Faltejskova, Adela Souckova, Sabina Sevcikova + 1 more
'Sabina Sevcikova' 'Roman Hajek'] Multiple myeloma (MM) is the second most common hematooncological disease of malignant plasma cells in the bone marrow. While new treatment brought unprecedented increase of survival of patients, MM pathogenesis is yet to be clarified. Increasing evidence of expression of long…