8 papers · ranked by Valyu relevance
Akram Baraa, Hekmat Ahmed, Mohammed Mohammed, Ahmed Abed
Background Colorectal carcinoma is among the most prevalent malignancies worldwide. PD-L1 is an immune-checkpoint ligand that can contribute to tumor immune evasion whereas BCL2 is an anti-apoptotic protein involved in cell-survival pathways, with its mutation frequently observed in various human cancers. This study…
Vincent Rothweiler, Christoph Roderburg, Muemtaz Koeksal, Björn Erik Ole Jensen + 7 more
4## Discussion This revised meta-analysis demonstrates a robust survival advantage for first-line PD-1 inhibitor-based therapy in advanced or metastatic ESCC, with a pooled OS HR of 0.68 and low statistical heterogeneity by I2. The magnitude of effect is clinically meaningful and aligns with the direction and size of…
Constantin Klenner, Josef Singer
4## Conclusion This case, together with the limited published evidence, suggests that PD-1/PD-L1 blockade may provide clinically meaningful and durable disease control in selected patients with multiply relapsed or refractory ALCL after established treatment options have been exhausted. The sustained complete metabolic…
Dave Maurice De Sousa, Salix Boulet, Frédéric Duval, Eric Perkey + 9 more
During chronic infection, the persistence of antigen and inflammation leads to the differentiation of CD8^+^ T cells into an exhausted state characterised by expression of inhibitory receptors (IRs) and the progressive loss of T cell functions. Among the different subsets of exhausted CD8^+^ T (Tex) cells, Tex…
Lei Li
Carefully selected elderly patients with metastatic PSCC may obtain a durable complete response via tislelizumab chemoimmunotherapy combined with metformin and standardized MDT management, providing practical clinical reference for high-risk elderly lung cancer patients complicated with multiple comorbidities.
Manuel Weber, Leah Trumet, Fabienne Lange, Julia Murk + 8 more
Purpose Combination immunotherapy has shown encouraging activity across multiple solid tumors. We report the complete and consecutive cohort of patients with locally advanced oral squamous cell carcinoma (OSCC) treated at a single center within the prospective, multicenter, randomized phase 2 BelieveIT-201 trial…
Gonçalo Trindade, Giacomo Domenici, Miguel Pinto, Viviana Correia + 5 more
Immunosuppressive tumor microenvironments (TMEs) are common in breast cancer (BC), where tumor-promoting myeloid-driven inflammation contributes to immune dysfunction and poor immunotherapy response. Lectins expressed by tumor-associated macrophages (TAMs) act as glycan-sensing immunoregulatory receptors driving…
Nassima Fodil, Esther Del Cid-Pellitero, Valerio E.C. Piscopo, Julia Xiao Xuan Luo + 20 more
Neuroinflammation strongly contributes to the pathogenesis of neurological and neurodegenerative diseases, including Parkinson’s disease (PD). We show that ablation of Usp15 in astrocytes and in microglia protects against lethal neuroinflammation in vivo. In a mouse model of synucleinopathy, Usp15 deletion diminishes…