5 papers · ranked by Valyu relevance
Nhan Ly-Trong, Samuel Martin, Nick Goldman, Nicola De Maio + 1 more
Phylogenetic analysis is essential to genomic epidemiology, for example in tracing the origin and evolution of SARS-CoV-2 variants during the COVID-19 pandemic. We previously introduced CMAPLE, a single-threaded implementation of the MAPLE algorithm designed for large-scale epidemiological genomic datasets. CMAPLE can…
Sumesh Kumar, Joseph Zambreno, Ashfaq Khokhar, Shoaib Akram + 1 more
Improving the speed and efficiency of database search algorithms that deduce peptides from mass spectrometry (MS) data has been an active area of research for more than three decades. The significance of the need for faster database search methods has rapidly increased due to the growing interest in studying non-model…
Max Ward, Mary Richardson, Haining Lin, Michael Stamm + 7 more
mRNA medicines hold great promise, but designing sequences with high translation efficiency, robust in-solution stability, and manufacturability remains a major challenge due to the vast combinatorial space of synonymous coding sequences. Computational approaches such as mRNA folding algorithms have emerged as powerful…
Rick Beeloo, Ragnar Groot Koerkamp
Searching short DNA patterns such as barcodes, primers, or CRISPR spacers within sequencing reads or genomes is a fundamental task in bioinformatics. These problems are instances of multiple approximate string matching (MASM) [1], which requires locating all occurrences with up to k errors of multiple patterns of…
Jose L Figueroa, Richard Allen White
We now exist in the era of massive datasets from genomics, large language models, and all the known knowledge of humanity right at our fingertips. Much of this data is becoming more accessible; however, processing such data remains an ongoing issue across systems including high performance computing (HPC)…