17 papers · ranked by Valyu relevance
Aial Sobeh, Simone Shamay-Tsoory, Bruno Kluwe-Schiavon, Giorgio Manenti
Human behavior is shaped by a pervasive motive to align with others, manifesting across a wide range of tendencies-from motor synchrony and emotional contagion to convergence in beliefs and choices. Existing accounts explain how alignment arises through predictive coding and observation-execution mechanisms, but they…
Mario Treviño, Nathaly Martín, Andrea Barrera, Inmaculada Márquez + 1 more
Highlights What are the main findings?1. Successful interception exhibits within-trial, speed-dependent shifts between predictive and reactive control in both gaze and manual trajectories. 2. Target occlusion reduces predictive alignment, whereas cursor occlusion has a limited impact, indicating strong reliance on…
Rattan Khurana, Archana, Kanish Aggarwal, Sharvari Bhat + 3 more
Clear aligner therapy often encounters early tracking deviations that compromise treatment efficiency, creating a need for predictive tools that identify risk at the outset. Therefore, it is of interest to develop and validate a deep morphometric AI model capable of forecasting early aligner tracking deviation using…
Rofaida Mohamed Elsayed, Ibrahim M. Moustafa, Abdulla Alrahoomi, Mishal M. Aldaihan + 3 more
Background: This study investigated how static postural parameters influence dynamic spinopelvic balance across varying walking speeds. One hundred healthy young adults (aged 18-25) underwent rasterstereographic assessment (DIERS 4Dmotion®) to quantify static global alignment metrics including craniovertebral angle…
Prasetia Utama Putra, Fumihiro Kano
A central challenge in understanding joint action is explaining how individuals achieve successful coordination in dynamic, real-world settings. Although coordination is thought to depend on anticipating future events, including the actions of others, the precise contribution of such predictive processing remains…
Nimrod Serok, Ksenia Polonsky, Haim Ashkenazy, Itay Mayrose + 3 more
Multiple sequence alignment (MSA) inference is a central task in molecular evolution and comparative genomics, and the reliability of downstream analyses, including phylogenetic inference, depends critically on alignment quality. Despite this importance, most widely used MSA methods optimize the sum-of-pairs (SoP)…
Yixiao Zhai, Zitong Zhang, Zhen Li
The reliability of multiple sequence alignment (MSA) results directly determines the credibility of the conclusions drawn from biological research. However, MSA is inherently an NP-hard problem, making it theoretically impossible to guarantee a globally optimal solution. Consequently, in addition to developing more…
Leonard Sasse, Casey Paquola, Juergen Dukart, Felix Hoffstaedter + 2 more
Functional connectivity (FC) gradients derived from fMRI provide valuable insights into individual differences in brain organisation, yet aligning these gradients across individuals poses challenges for meaningful group comparisons. Procrustes alignment is often employed to standardize gradients, but the choice of the…
Minsoo Kim, Hanjin Bae, Gyeongpil Jo, Kunwoo Kim + 3 more
We evaluated OTalign on three established remote-homology benchmarks-SABmark (), MALIDUP (), and MALISAM ()-which together cover complementary aspects of protein sequence alignment under low similarity conditions (see Supplementary Section S3, available as [sup1] at Bioinformatics online for dataset statistics and…
Luca Renders, Lore Depuydt, Travis Gagie, Jan Fostier + 1 more
Lossless alignment tools are crucial for certain bioinformatics applications, including Human Leukocyte Antigen (HLA) typing from next-generation sequencing (NGS) data. Accurate, high-resolution HLA typing is essential for understanding immune system function and has significant applications in organ transplantation…
Felix Kallenborn, Fawaz Dabbaghie, Martin Steinegger, Bertil Schmidt
Background The continually increasing volume of sequence data results in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments based on dynamic programming is an important part in many bioinformatics pipelines and a major contributor to overall runtime due to the associated…
Paul A Gagniuc, Elvira Gagniuc
Sequence alignment provides a formal framework for comparison of biological sequences through score maximization over matches, mismatches, and insertion-deletion events. Classical formulations distinguish between global alignment, which enforces end-to-end correspondence through fixed boundary conditions, and local…
Horia Todor, Lili M Kim, Jürgen Jänes, Hannah N Burkhart + 3 more
Accurate prediction of protein complex structures by AlphaFold3 and similar programs has been used to predict the presence of protein-protein interactions (PPIs), but this technique has never been applied to an entire genome due to onerous computational requirements and questionable utility. Here we present pooled-PPI…
Mattijn Wagt, Cristina Teodosio, Anniek L. de Jager, Jacques J.M. van Dongen + 3 more
Peptides are versatile tools in immunotherapy, serving as vaccines and targets for specific immunotherapeutic strategies. Peptides engage immune cells like macrophages and T cells, enabling precise modulation of immune responses. In this context, we highlight the utility of macrophages, innate immune cells involved in…
Hyun-Jin Jung, Yun-Ho Lee, ChungGen Lee, Seong-Woo Cho + 1 more
Rice grain protein content exhibits substantial inter-annual variability due to interactions between management practices and environmental conditions, making robust prediction under realistic field conditions challenging. This study evaluated the year-independent predictability of rice grain protein content using…
Faiza Hasin, Michele Minervini, Corrado Mencar, Giuseppe Ventrella + 3 more
Introduction The interaction between guide RNAs (gRNAs) and target DNA sequences is a critical factor in the effectiveness of CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9) gene editing. Predicting these interactions accurately necessitates models that offer…
Joy Chenqu Lyu, Renier A. L. Van der Hoorn
Title: SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai-1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This…