11 papers · ranked by Valyu relevance
Paul Kroll, Alexandra Hofer, Sophia Ulonska, Julian Kager + 1 more
'Christoph Herwig'] Model-based methods are increasingly used in all areas of biopharmaceutical process technology. They can be applied in the field of experimental design, process characterization, process design, monitoring and control. Benefits of these methods are lower experimental effort, process transparency…
Markus Martini, Jakob Pinggera, Manuel Neurauter, Pierre Sachse + 2 more
'Marco R. Furtner' 'Barbara Weber'] A process model (PM) represents the graphical depiction of a business process, for instance, the entire process from online ordering a book until the parcel is delivered to the customer. Knowledge about relevant factors for creating PMs of high quality is lacking. The present study…
Ahmed BaniMustafa, Nigel Hardy
This work demonstrates the execution of a novel process model for knowledge discovery and data mining for metabolomics (MeKDDaM). It aims to illustrate MeKDDaM process model applicability using four different real-world applications and to highlight its strengths and unique features. The demonstrated applications…
Jovan Tanevski, Ljupčo Todorovski, Sašo Džeroski
Background Identifying a proper model structure, using methods that address both structural and parameter uncertainty, is a crucial problem within the systems approach to biology. And yet, it has a marginal presence in the recent literature. While many existing approaches integrate methods for simulation and parameter…
Reema Choudhary, Nauman Riaz, Jacopo Soldani
Software reverse engineering and reengineering are becoming common in the field of games and website development. Simulation and modeling play an important role in understanding the flow of the overall system. Business process modeling notation (BPMN) is used to show the overall architecture of the business process.…
Julia Baß, Michael Winter, Rüdiger Pryss, Manfred Reichert + 1 more
'Daniele Corbo'] The study of complex process models often encounters challenges in terms of comprehensibility. This paper explores using modularization as a strategy to mitigate such challenges, notably the reduction in complexity. Previous research has delved into the comprehensibility of modularized process models…
Otilia Carvalho, Maria N. Charalambides, Ilija Djekić, Christos Athanassiou + 16 more
'Christos Athanassiou' 'Serafim Bakalis' 'Jose Benedito' 'Aurelien Briffaz' 'Cristina Castañé' 'Guy Della Valle' 'Isabel Maria Nunes de Sousa' 'Ferruh Erdogdu' 'Aberham Hailu Feyissa' 'Nickolas G. Kavallieratos' 'Alexandros Koulouris' 'Milica Pojić' 'Anabela Raymundo' 'Jordi Riudavets' 'Fabrizio Sarghini' 'Pasquale…
Johannes Hemmerich, Niklas Tenhaef, Wolfgang Wiechert, Stephan Noack
Quantitative characterization of biotechnological production processes requires the determination of different key performance indicators (KPIs) such as titer, rate and yield. Classically, these KPIs can be derived by combining black-box bioprocess modelling with non-linear regression for model parameter estimation.…
Alessandra Livigni, Laura O’Hara, Marta E. Polak, Tim Angus + 2 more
In silico modelling of biological pathways is a major endeavour of systems biology. Here we present a methodology for construction of pathway models from the literature and other sources using a biologist-friendly graphical modelling system. The pathway notation scheme, called mEPN, is based on the principles of the…
Marvin van Aalst, Oliver Ebenhöh, Anna Matuszyńska
Computational mathematical models of biological and biomedical systems have been successfully applied to advance our understanding of various regulatory processes, metabolic fluxes, effects of drug therapies and disease evolution or transmission. Unfortunately, despite community efforts leading to the development of…
Ron Henkel, Robert Hoehndorf, Tim Kacprowski, Christian Knüpfer + 2 more
Computational models used in biology are rapidly increasing in complexity, size, and numbers. To build such large models, researchers need to rely on software tools for model retrieval, model combination, and version control. These tools need to be able to quantify the differences and similarities between computational…