3 papers · ranked by Valyu relevance
Steven M. Muskal, Malcolm J. McGregor
A three-dimensional pharmacophore fingerprint records the binding features a molecule can present. It is a description of a hand in search of a glove. Because it is defined by presented features instead of two-dimensional structure, it can identify pharmacophoric similarity between structurally distinct compounds…
Peng Wang, Zixiong Fan, Haoyu Wu, Kaijiao Wang + 4 more
Accurate preoperative segmentation of colorectal cancer lymph node metastasis holds significant clinical value for formulating individualized surgical strategies. However, accurate segmentation remains a formidable challenge due to the complex backgrounds, small sizes, irregular shapes, and indistinct boundaries…
Amélie Barozet, Vincent Cabeli, Jean Ogier du Terrail, Alexey Rukhovich + 6 more
The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active…