11 papers · ranked by Valyu relevance
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht + 2 more
Wilms tumors present as an amalgam of varying proportions of three tissues normally located within the developing kidney, one being the multipotent nephron progenitor population. While incomplete differentiation of the nephron progenitors is widely-considered the underlying cause of tumor formation, where this barrier…
Matthew J. Stevenson, Sabrina K. Phanor, Urvi Patel, Stephen S. Gisselbrecht + 2 more
'Stephen S. Gisselbrecht' 'Martha L. Bulyk' "Lori L. O'Brien"] Title: ABSTRACT Wilms tumors present as an amalgam of varying proportions of tissues located within the developing kidney, one being the nephrogenic blastema comprising multipotent nephron progenitor cells (NPCs). The recurring missense mutation Q177R in…
Amelia Carolina Sparavigna
Previous studies (Sparavigna, 2023) have demonstrated the Tsallis q-Gaussian functions suitable for the analysis of Raman spectra. Here we consider two asymmetric forms of them, with the aim of further improving the fitting of Raman spectra. The first asymmetric form, that we are here proposing for the first time, is a…
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi + 1 more
Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 to cell surface receptors IL-27Rα and gp130 results in activation of receptor-associated Janus Kinases and nuclear translocation of STAT1 and…
Authors not listed
Quinone reduction is a key step in catalysis by respiratory complex I (NADH:quinone oxidoreductase, RCI), an essential energy-transducing enzyme that drives ATP synthesis by oxidative phosphorylation. However, the mechanism of quinone reduction and the role of semiquinone (SQ) intermediates in catalysis remain poorly…
Matt Landreman
A method is demonstrated to rapidly calculate the shapes and properties of quasiaxisymmetric and quasi-helically symmetric stellarators. In this approach, optimization is applied to the equations of magnetohydrodynamic equilibrium and quasisymmetry, expanded in the small distance from the magnetic axis, as formulated…
Matt Landreman, Elizabeth Paul
Quasisymmetry is an unusual symmetry that can be present in toroidal magnetic fields, enabling confinement of charged particles and plasma. Here it is shown that both quasi-axisymmetry and quasi-helical symmetry can be achieved to a much higher precision than previously thought over a significant volume, resulting in…
Inci Sardag, Zeynep Sevval Duvenci, Serkan Belkaya, Emel Timucin
Interleukin (IL) 37 is an anti-inflammatory cytokine belonging to the IL1 protein family. Owing to its pivotal role in modulating immune responses, particularly through interfering with the IL18 signaling, elucidating the IL37 complex structures holds substantial therapeutic promise for various autoimmune disorders and…
Hui Zhang, Xiao-chen Bai, Xuewu Zhang
The IL-17 receptors (IL-17Rs) play critical roles in immunity and inflammatory diseases. IL-17-induced heteromeric complexes between IL-17RA and another IL-17R trigger signaling by binding the downstream transducer ACT1 through interactions between their intracellular SEF/IL-17R (SEFIR) domains. The molecular mechanism…
Amr M. Sobeh, Catherine D. Eichhorn
The 7SK ribonucleoprotein (RNP) is a critical regulator of eukaryotic transcription. Recently, RNA binding motif 7 (RBM7), which contains an RNA recognition motif (RRM), was reported to associate with 7SK RNA and core 7SK RNP protein components in response to DNA damage. However, little is known about the mode of…
Tongxia Jin, Luling Wu, Ti Jia, Rongrong Zhao + 6 more
Vicinal dithiol-containing proteins (VDPs) are of considerable importance due to their role in regulating cellular functions through the reversible dithiol/disulfide inter-conversion reaction. However, there are currently no effective tools for the simultaneous tracing of endogenous VDPs in live cells. Here, we report…