Search · four archives
Search · four archives
6 papers · ranked by Valyu relevance
David Haussler, Maciej Smuga-Otto, Benedict Paten, Adam M Novak + 3 more
Efforts to incorporate human genetic variation into the reference human genome have converged on the idea of a graph representation of genetic variation within a species, a genome sequence graph. A sequence graph represents a set of individual haploid reference genomes as paths in a single graph. When that set of…
Peter L. Bartlett, Chris Junchi Li, Jingfeng Wu, Bin Yu
In the field of optimization, developing accelerated methods for solving minimax and fixed-point problems remains a fundamental challenge. This paper presents a novel family of dual accelerated algorithms that achieve optimal convergence rates for both minimax and fixed-point problems. By exploring new anchoring…
Richard A. Neher
Shared ancestry among individuals results in correlated traits and these dependencies need to be accounted for in probabilistic inference. In strictly asexual populations, the covariances have a particularly simple block-like structure imposed by the phylogenetic tree. Ho and Ane showed how this block-like structure…
Yiteng Zhang, Zixiong Wang, Xingyu Li, Bin Min
Inferring computational mechanisms from neural recordings is a central goal in systems neuro-science. Recent developments have identified low-rank recurrent neural networks (RNNs) as an effective tool for fitting observed neural activity and extracting neural dynamics. However, we show that accurate activity fitting…
Sangyeon Lee, Hanjin Kim, Doheon Lee
Regression analysis is one of the most widely applied methods in many fields including bio-medical study. Dimensionality reduction is also widely used for data preprocessing and feature selection analysis, to extract high-impact features from the predictions. As the complexity of both data and prediction models…
Maria Filipa Pinto, Jorge Ripoll-Rozada, Helena Ramos, Emma E. Watson + 7 more
Enzymes are among the most important drug targets in the pharmaceutical industry. The bioassays used to screen enzyme modulators can be affected by unaccounted interferences such as time-dependent inactivation and inhibition effects. Using procaspase-3, caspase-3, and α-thrombin as model enzymes, we show that some of…