19 papers · ranked by Valyu relevance
Amir Hossein Ghasemi
We present a relational framework in which temporal structure is not fundamental but emerges from correlations within a globally stationary quantum state. Each subsystem includes an internal clock, and conditional states evolve effectively with respect to these internal readings. The construction naturally extends to…
Partha Nandi, Francesco Petruccione
Markovian open quantum theory assumes evolution with respect to an external classical time parameter, yet no preferred notion of time exists fundamentally in relativistic physics. We resolve this tension by formulating relativistic open quantum dynamics relationally through finite-resolution quantum clocks. Using the…
Zambianco, Matheus H., Perche, T. Rick
1 Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada 2 Perimeter Institute for Theoretical Physics, Waterloo, Ontario, N2L 2Y5, Canada 3 Institute for Quantum Computing, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada 4 Nordita, KTH Royal Institute of Technology and…
Matias Slavov
Conventional elements play an integral role in measuring time. Clocks unavoidably require a chosen standard of synchrony. The periodic process selected for the standard is not imposed upon us in any way. Conventionalism, in this regard, offers an insightful perspective on temporal measurement. The strong formulation of…
Mesfin Asfaw Taye
Across adult warm-blooded vertebrates, the product of resting heart rate f_H_ and maximum lifespan L is approximately constant: N_⋆_ = f_H_ L ≈ 10^9^ cardiac cycles. This empirical regularity, noted since Rubner (1908), has lacked a widely accepted thermodynamic interpretation. We derive N_⋆_ ≈ 10^9^ from the…
Vishal, Malay K. Nandy
We investigate the problem of classical big bang singularity in a plane-symmetric Bianchi type-I universe within the Wheeler-DeWitt (WDW) framework of quantum gravity. To address the problem of time, we employ the Page-Wootters formalism, which provides a relational notion of dynamics by conditioning the global state…
Justin Eilertsen, Santiago Schnell, Sebastian Walcher
Drug-target occupancy time—the cumulative duration a target remains bound—critically influences therapeutic efficacy. While Copeland’s widely-used residence time (1/k_off_) emphasizes dissociation kinetics, it neglects association rates, rebinding events, and drug elimination that affect in vivo outcomes. Returning to…
Authors not listed
Linking molecular interactions to the macroscopic mechanical properties of soft materials has remained a major challenge in soft-matter science. In this work, we developed metal–polymer soft framework (MPF) ion gels, in which metal–ligand coordination complexes act as dynamic cross-linking points within a structurally…
Nobuko Irie, Omnia Reda, Yorifumi Satou, Masahiro Ono
Cell-state transitions during development are shaped by multiple concurrent processes, yet single-cell transcriptomic analyses often rely on static molecular profiles or infer time without an experimental anchor. We developed mCanonicalTockySeq, a systems-level framework that reconstructs temporally resolved…
Simona Ivanov, Samuel Fosse, Mario dos Reis, Sebastian Duchene
Bayesian inference of divergence times for extant species using molecular data is an unconventional statistical problem: Divergence times and molecular rates are confounded, and only their product, the molecular branch length, is statistically identifiable. This means we must use priors on times and rates to break the…
Yuan Xu, Jordan Douglas, Remco R. Bouckaert, Alexei J. Drummond
Conditioning the inference of a Bayesian phylogenetic time tree on a single molecular clock model treats clock choice as fixed, even when support among plausible clock families is uncertain. When that assumption is wrong, estimated timescales and their uncertainty can be distorted. Existing practice usually addresses…
Authors not listed
Atomistic simulations provide essential mechanistic insights into chemical processes, yet many important phenomena in chemistry and materials science occur on timescales that are inaccessible to molecular dynamics. Existing computational approaches force a choice between atomic resolution on relatively short timescales…
Amelie Müller, Timo Diepers, Arthur Jakobs, Giuseppe Cardellini + 3 more
Purpose A well-known limitation of conventional Life Cycle Assessment (LCA) is the lack of temporal considerations, particularly the temporal distribution and evolution of processes, emissions, and environmental responses. While these aspects have been explored to some extent in dynamic and prospective LCA, a…
Paweł Gładysz, Dorota Bielińska-Wąż, Piotr Wąż, Małgorzata Samorek-Pieróg + 2 more
We investigated the mitochondrial genetic diversity of Echinococcus multilocularis in red foxes from northern and northeastern Poland, and tested the hypothesis that the presence of Asian haplotypes in Poland stems from their introduction from Northeast Asia to Eastern Europe. We targeted the cytochrome c oxidase…
Lucas Lacasa
Temporal networks, defined as sequences of time-aggregated adjacency matrices, sample latent graph dynamics and trace trajectories in graph space. By interpreting each adjacency matrix as a different time snapshot of a scalar field, we show how fluid-mechanics methods can be applied to construct two distinct…
Thiago S. Messias, Kaique C. P. Silva, Narciso A. Vieira, Gislaine A. Querino + 13 more
Filoviruses are among the most lethal viral human pathogens known, with significant relevance to public health, yet their evolutionary history remains poorly resolved. This study applied a multiprotein molecular phylogenetic approach to investigate the evolutionary and temporal dynamics of the family Filoviridae. Amino…
Baochen Li, Alfiya Abinova, Shouwei Li
Temporal networks capture systems whose interactions occur as time-stamped events, where resilience depends on whether time-respecting connectivity can be maintained under disruptions. Existing assessments often rely on static aggregation or path-centric indicators, which may overlook higher-order redundancy that…
Hans-Joachim Lenz, Simon Forstmeier, Lukas Flöter, Nik Hulsmans
Purpose This study aims to provide evidence on how to best capture balancedness in temporal framing. Balancedness is assumed to be adaptive, predicting well-being and other indicators of mental health. Additionally, time perception is fundamental to human functioning, directing time perspectives (TP) toward past…
Virginie van Wassenhove, Benjamin R. Kanter, Simone Viganò, Raphaël Bordas
In a dense-sampling resting-state functional magnetic resonance imaging study, [15] recorded two individuals’ functional connectivity patterns over 30 consecutive days to find a marker of the passage of time in the human brain. The authors measured the similarity of brain connectivity patterns over days, focusing on…