9 papers · ranked by Valyu relevance
Natalie A Steinemann, Gabriel M Stine, Eric M Trautmann, Ariel Zylberberg + 2 more
Neurobiological investigations of perceptual decision-making have furnished the first glimpse of a flexible cognitive process at the level of single neurons^1,2^. Neurons in the parietal and prefrontal cortex^3–6^ are thought to represent the accumulation of noisy evidence, acquired over time, leading to a decision.…
Caroline Haimerl, Cristina Savin, Eero P. Simoncelli
Sensory-guided behavior requires reliable encoding of information (from stimuli to neural responses) and flexible decoding (from neural responses to behavior). In typical decision tasks, a small subset of cells within a large population encode task-relevant stimulus information and need to be identified by later…
Caroline Haimerl, Douglas A. Ruff, Marlene R. Cohen, Cristina Savin + 1 more
Sensory-guided behavior requires reliable encoding of stimulus information in neural responses, and task-specific decoding through selective combination of these responses. The former has been the topic of intensive study, but the latter remains largely a mystery. We propose a framework in which shared stochastic…
K. J. Painter, V. Giunta, J. R. Potts, S. Bernardi
In a chase-and-run dynamic, the interaction between two individuals is such that one moves towards the other (the chaser), while the other moves away (the runner). Examples can be found in both interacting cells and interacting animals. Here we investigate the behaviours that can emerge at a population level, for a…
Jackson Champer, Isabel Kim, Samuel E. Champer, Andrew G. Clark + 1 more
Rapid evolutionary processes can produce drastically different outcomes when studied in panmictic population models versus spatial models where the rate of evolution is limited by dispersal. One such process is gene drive, which allows “selfish” genetic elements to quickly spread through a population. Engineered gene…
Jia Lu, Ryan Tsoi, Nan Luo, Yuanchi Ha + 8 more
Dynamical systems often generate distinct outputs according to different initial conditions, and one can infer the corresponding input configuration given an output. This property captures the essence of information encoding and decoding. Here, we demonstrate the use of self-organized patterns, combined with machine…
Anush Mahajan, Bhaswar Ghosh
Living organisms are required to sense the environment accurately in order to ensure appropriate responses. The cells utilize specific signaling pathways to estimate the signal. The accuracy of estimating the input signal is severely limited by noise stemming from inherent stochasticity of the chemical reactions…
Maximilian Gehri, Lukas Stelzl, Heinz Koeppl
Biochemical systems process signals through stochastic reaction dynamics that are inherently continuous in time and often exhibit memory, feedback, and nonequilibrium driving. At the same time, they are frequently modeled by effective reactions, e.g., multi-step processes such as transcription are treated as single…
Kevin D. Volkel, Paul W. Hook, Albert Keung, Winston Timp + 1 more
As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and…