11 papers · ranked by Valyu relevance
Hiroyuki Kusano, Takayuki Shiomi
Digital pathology has rapidly expanded over the past decade, driven by advances in whole-slide imaging and increasing demand for remote and data-integrated diagnostic workflows. However, many implementations remain limited to partial digitization, without fundamentally transforming laboratory and diagnostic processes.…
Xuebin Feng, Emma R. Master
Sequence similarity networks (SSNs) are graphical representations of sequence relationship frequently used for exploring protein sequence space. Conventional SSN workflows typically use BLAST to calculate sequence similarities and rely on external visualization tools to generate the final networks. Consequently, raw…
Xianshengjie Lang, Changbin Zhang, Jingxuan Lin, Zhe Zhang + 3 more
Cell-free protein synthesis (CFPS) systems are a powerful platform with immense potential in fundamental research, biotechnology, and synthetic biology. Conventional prokaryotic CFPS systems, particularly those derived from Escherichia coli, often rely on complex reaction buffers containing up to 35 components…
Huihai Wu, Ashleigh Lister, Iain Macaulay, Katie Long + 10 more
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck. Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial…
Odin Zhang, Jiaqi Wang, Tuscan Rock Thompson, Ziyi You + 3 more
Biomolecular interactions, including protein–protein interactions, protein–nucleic acid recognition, and protein–small molecule binding, underlie a wide range of biological processes and therapeutic mechanisms. Although recent de novo design methods can generate candidate binders for diverse molecular targets…
Atif Khan, Sruti Chandramouli, Hiren M. Joshi
The crystal violet (CV) microtiter plate assay is widely used to compare microbial biofilm formation because it is inexpensive, simple, and readily adapted to 96-well formats. Its high-throughput design enables multiple strains, growth conditions, and treatments to be tested in parallel, but increasing experimental…
Ruben M van de Wijdeven, Naomi S de Ruijter, Femke C C Kremers, Esmee Venema + 10 more
The prehospital triage of patients with a suspected acute stroke (PRESTO-2) study is a prospective multicentre non-randomised controlled before-and-after intervention trial. The primary and secondary objectives require different analytical approaches and are therefore described separately below. For the primary…
Mohamed Selmy, A. Abdulnabi, A. A. Ali, E. M. Saied + 1 more
Nanogrids have emerged as a crucial solution for contemporary residential power systems, providing a robust framework for integrating distributed energy resources (DERs), comprising solar photovoltaics (PVs), wind turbines (WTs), energy storage systems (ESSs), and diesel generators (DGs). However, the uncertainty of…
Junjie Yao, Zhongxu Li, Cuiping Wang, Junyu Wu + 3 more
A motion control strategy based on multi-source heterogeneous motion information fusion and motion decoupling parallel washout algorithm (WA) is proposed for the control of a rehabilitation robot designed for stroke-related balance disorders. The robot features a serial-parallel hybrid structure and humanoid gait…
Namasi G Sankar, Georgios Miliotis, Simon Caton
Genome assembly is important in infectious disease surveillance, antimicrobial resistance monitoring, and cancer genomics. The task of reconstructing full genomic sequences from fragmented reads, can be framed as a large scale combinatorial optimisation problem. Recent advances in quantum computing have introduced new…
Peter F. Pelz, Tobias Meck
For nearly a century, the physical origin of metabolic scaling has remained unresolved: metabolism is proportional to body mass in small organisms but follows Kleiber’s three-quarter-power law in larger animals. We derive both regimes from the Metabolic Holon (MH), a locally optimized capillary–tissue oxygen-supply…