22 papers · ranked by Valyu relevance
Kevin J. Zhang, Lisa M. Monteggia, Ege T. Kavalali
Neuronal communication is governed by a diverse repertoire of neurotransmitter release modes, each with distinct molecular machinery and functional roles. Beyond rapid, high-fidelity synchronous release, asynchronous release supports sustained neurotransmitter output, while spontaneous, action-potential-independent…
Rana Mozumder, Zhengyang Wang, Wenhao Dang, Junda Zhu + 3 more
Persistent spiking activity and activity-silent mechanisms have been proposed as neural correlates of working memory. To determine their relative contribution, we recorded neural activity from the lateral prefrontal and posterior parietal cortex of two male macaques using high-density microelectrode probes. We found…
Rana Mozumder, Zhengyang Wang, Wenhao Dang, Junda Zhu + 3 more
Title: SUMMARY Persistent spiking activity and activity-silent mechanisms have been proposed as neural correlates of working memory. To determine their relative contribution, we recorded neural activity from the lateral prefrontal and posterior parietal cortex of two male macaques using high-density microelectrode…
Lu, Han, Liu, Zichen + 40 more
Han Lu12 ∗ , Zichen Liu1∗† , Shaopan Xiong1∗† , Yancheng He1 ∗ , Wei Gao3 ∗ , Yanan Wu∗,1, Weixun Wang1∗† , Jiashun Liu13, Yang Li12, Haizhou Zhao 1 , Ju Huang 1 , Siran Yang 1 , Xiaoyang Li 1 , Yijia Luo 1 , Zihe Liu 1 , Ling Pan 3 , Junchi Yan 2 , Wei Wang 3 , Wenbo Su 1 , Jiamang Wang 1 , Lin Qu 1 , Bo Zheng 1 1…
Doruk Efe Gökmen, Michel Fruchart, Dmitrii Zendrikov, Giacomo Indiveri + 2 more
Computation is the controlled evolution of a state. Asynchronous evolutions, where all parts of the state change in their own time without stopping each other, put this control in jeopardy. It is in fact a mystery how natural processes perform asynchronous computations using many units with no global orchestration.…
Bai, Huawei, Yifan Huang, Wenqi Shi + 5 more
The training efficiency and scalability of language models on massive clusters currently remain a critical bottleneck. Mainstream approaches like ND parallelism are often cumbersome and complex, while flexible alternatives such as the Zero Redundancy Optimizer (ZeRO) are frequently hampered by communication overhead.…
Dylan McDermott, Nobuko Yoshida
We provide the first denotational semantics for asynchronous multiparty session types with precise asynchronous subtyping. Our semantics enables us to reason about asynchronous message-passing, in which message-sending is non-blocking. It enables us to prove the correctness of communication optimisations, in…
Yuhan Bao, Hao Shi, Jiajun Zhai, Kaiwei Wang
Conventional imaging systems struggle to simultaneously achieve high-dynamic-range imaging under extreme illumination and ensure that visual data remain confidential from the moment of acquisition. Here we present Asynchronous Temporal Mapping, a framework that encodes high-dynamic-range visual information into a…
Dimitris Kotzadimitriou, Helen Langley, Eleanor McGowan, Philipe R. F. Mendonca + 4 more
Short-term synaptic plasticity and the kinetics of neurotransmitter release vary widely across synapses, but population measurements obscure the mechanisms that generate this diversity. While the Ca^2+^ sensor Synaptotagmin-7 (Syt7) has been implicated in facilitation, vesicle replenishment and asynchronous vesicle…
Shivam Shah, Ikaasa Suri, Helen Gordan, Nicole Schwartz + 7 more
Background Asynchronous care has emerged as a promising approach to improving healthcare accessibility while potentially reducing costs, particularly for low-acuity conditions. Our objective was to describe the use patterns, patient characteristics, and short-term clinical outcomes of an emergency department (ED)-led…
Zhenyu Li, Yong Ding, Ruwen Zhao, Shuo Wang + 2 more
With the widespread deployment of Industrial Cyber-Physical Systems (ICPS), their inherent vulnerabilities have increasingly exposed them to sophisticated cybersecurity threats. Although existing protective mechanisms can block attacks at runtime, the risk of defense failure remains. To proactively evaluate and harden…
Samuel Erickson, Mikael Johansson
In modern machine learning, parallelization of training is an important strategy for increasing scale. Asynchronous stochastic gradient descent (ASGD), which maximizes the utilization of available hardware by avoiding waiting for slow workers. However, with constant step sizes, the convergence of ASGD is nonetheless…
Authors not listed
We present graphRC, a graph-based method for rapid transition state (TS) mode analysis that provides chemical insight along normal mode displacements and reaction coordinate trajectories by translating Cartesian displacements into meaningful internal coordinate changes. Internal coordinates are constructed using…
Ravi Umadi
Echolocating bats operate within a closed sensorimotor loop in which call emission, echo reception, sensory processing, and motor response are linked by finite propagation delays and bounded response times. Although synchrony between wingbeats and call timing is frequently observed, it remains unclear when such…
Solène Leblond, Robin Baurès, Tutea Atger, Marina Poinsignon + 2 more
Audiovisual integration is essential for daily functions such as speech comprehension. It relies on a temporal constraint whereby events from different sensory modalities are perceptually bound within a limited temporal window, the audiovisual temporal binding window, defining the range of stimulus onset asynchronies…
Authors not listed
This study reports the formation of gold nanoparticle (AuNP) films by electrochemical assembly at the polarized water | trifluorotoluene interface (ITIES) and their use as SERS substrates whose activity can be tuned by the interfacial potential. Using a four-electrode configuration, cyclic modulation of the interfacial…
Vanessa Kern, Svenja Capitain, Gwendolyn Wirobski, Pablo Arias-Sarah + 3 more
Chorus howls play a central role in wolves’ (Canis lupus) social communication, shaping both intra- and inter-pack interactions. While synchrony has been shown to influence perceived threat from outgroups in birds and humans, whether the synchrony of an outside pack’s chorus howl plays a role in wolf pack behaviour…
Bojie Li
Hardware accelerators now sit on the critical path of online serving. GPUs, FPGAs, and increasingly remote services such as hardware security modules, post-quantum KEMs, and inference servers. For fine-grained offloads (microseconds to a few milliseconds) the classic responses to the resulting stall both fail: a…
Eleonora Marcantoni, Danying Wang, Kimron L. Shapiro, Simon Hanslmayr
Theta-phase synchronisation between visual and auditory rhythmically modulated sensory stimuli during encoding has been shown to enhance associative memory, an effect known as Theta-Induced Memory Effect (TIME). However, whether this advantage is short-lived or persists over time remains unknown. To address this, we…
Authors not listed
Molecular dynamics simulations model chemical reactions as continuous changes in molecular structure over time in-stead of static minima and transition states. This perspective argues that time-dependent structural change is a crucial, but often overlooked, mechanistic feature as many reactions simply do not follow a…
Kyriakos Psarakis
| | Summary | | xi | |---|----------|---------------------------------------------------------------------|------| | | | Samenvatting | xiii | | | Περίληψη | | xv | | 1 | | Introduction | 1 | | | 1.1 | From the Metal to the Clouds. | 3 | | | 1.2 | Scalable Cloud Application Aspects | 5 | | | | 1.2.1 Cloud Runtimes &…
Francesco Paladino, Shulu Li, Edward A. Lee
—Distributed time-sensitive systems must balance timing requirements (availability) and consistency in the presence of communication delays and synchronization uncertainty. This paper presents maxwait, a simple coordination mechanism with surprising generality that makes these tradeoffs explicit and configurable. We…