13 papers · ranked by Valyu relevance
Mark R. Saddler, Ray Gonzalez, Josh H. McDermott
Perception is thought to be shaped by the environments for which organisms are optimized. These influences are difficult to test in biological organisms but may be revealed by machine perceptual systems optimized under different conditions. We investigated environmental and physiological influences on pitch perception…
Yang Shen, Julia Wang, Saket Navlakha
A fundamental challenge at the interface of machine learning and neuroscience is to uncover computational principles that are shared between artificial and biological neural networks. In deep learning, normalization methods, such as batch normalization, weight normalization, and their many variants, help to stabilize…
Samuel Granjeaud, Naoill Abdellaoui, Anne-Sophie Chrétien, Eloise Woitrain + 8 more
Innovation in cytometry propelled it to an almost “omic” dimension technique during the last decade. The application fields concomitantly enlarged, resulting in generation of high-dimensional high-content data sets which have to be adequately designed, handled and analyzed. Experimental solutions and detailed data…
Yilin Gao, Fengzhu Sun
Heterogeneity in different genomic studies compromises the performance of machine learning models in cross-study phenotype predictions. Overcoming heterogeneity when incorporating different studies in terms of phenotype prediction is a challenging and critical step for developing machine learning algorithms with…
Alexander Lin, Alex X. Lu
Data collected by high-throughput microscopy experiments are affected by batch effects, stemming from slight technical differences between experimental batches. Batch effects significantly impede machine learning efforts, as models learn spurious technical variation that do not generalize. We introduce batch effects…
Benjamin R. Babcock, Astrid Kosters, Junkai Yang, Mackenzie L. White + 1 more
Single-cell RNA sequencing (scRNA-seq) can reveal accurate and sensitive RNA abundance in a single sample, but robust integration of multiple samples remains challenging. Large-scale scRNA-seq data generated by different workflows or laboratories can contain batch-specific systemic variation. Such variation challenges…
Beibei Wang, Fengzhu Sun, Yihui Luan
The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze microbiome data, it is essential to account for inherent heterogeneity and variability across samples. Normalization methods…
Max F. Burg, Santiago A. Cadena, George H. Denfield, Edgar Y. Walker + 3 more
Deep convolutional neural networks (CNNs) have emerged as the state of the art for predicting neural activity in visual cortex. While such models outperform classical linear-nonlinear and wavelet-based representations, we currently do not know what computations they approximate. Here, we tested divisive normalization…
Michiel Bongaerts, Ramon Bonte, Serwet Demirdas, Ed H. Jacobs + 7 more
Untargeted metabolomics is an emerging technology in the laboratory diagnosis of inborn errors of metabolism (IEM). In order to judge if metabolite levels are abnormal, analysis of a large number of reference samples is crucial to correct for variations in metabolite concentrations resulting from factors such as diet…
Miao Yu, Anna Roszkowska, Janusz Pawliszyn
Batch effects will influence the interpretation of metabolomics data. In order to avoid misleading results, batch effects should be corrected and normalized prior to statistical analysis. Metabolomics studies are usually performed without targeted compounds (e.g., internal standards) and it is a challenging task to…
Beibei Wang, Yihui Luan
Significant advancements have been made in metagenomic research for the prediction of phenotypes based on microbiome data. While qualitative case-control predictions have received significant attention, less emphasis has been placed on predicting quantitative phenotypes. This emerging field holds great promise in…
Alexis Vandenbon
Gene co-expression analysis is an attractive tool for leveraging enormous amounts of public RNA-seq datasets for the prediction of gene functions and regulatory mechanisms. However, the optimal data processing steps for the accurate prediction of gene co-expression from such large datasets remain unclear. Especially…
Xu Pan, Ruben Coen-Cagli, Odelia Schwartz
Convolutional neural networks (CNNs) have been used to model the biological visual system. Compared to other models, CNNs can better capture neural responses to natural stimuli. However, previous successes are limited to modeling mean responses; while another fundamental aspect of cortical activity, namely response…