6 papers · ranked by Valyu relevance
Yoshita Sriramkumar, Rhea Wali, Kasturi Mitra
The quiescent adult stem cells are activated to maintain tissue integrity. Mitochondria have emerged as critical regulators of stem/progenitor cells. Scattered literature suggests existence of a high-potency stemness state with characteristic mitochondrial structure-function properties that may ‘prime’ stem cell…
Huihai Wu, Ashleigh Lister, Iain Macaulay, Katie Long + 10 more
Single-cell and spatial transcriptomics are transforming our understanding of cellular heterogeneity and tissue organization, yet their analytical complexity remains a major bottleneck. Here, we present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial…
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang + 7 more
Title: Significance Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults and is projected to affect approximately 288 million people worldwide by 2040. Identifying the genes and cellular mechanisms underlying established AMD risk loci is essential for…
Cheryl Kim, Denise Hinz, Aaron Middlebrook, Aaron J Tyznik + 4 more
Circulating cell-cell complexes (doublets) provide critical insights into in vivo immune interactions. Here, we leverage high-dimensional imaging spectral cytometry to systematically map the landscape of immune doublets in human peripheral blood. By integrating morphometric imaging features with a 22-color spectral…
Yao Shen, Ziyang Yu, Qinfeng Zhu, Zhiyong Zhao + 7 more
Bridging the gap between macroscopic neuroimaging and microscopic histology remains a challenge in neuroscience. Here, we present a technical feasibility study of diffusion MR microscopy (dMRM) in the ex vivo human hippocampus using a 14.1 T ultrahigh-field MRI system. Mid-hippocampal blocks from control and…
John Tower
Biological information is generally thought to be subject to selection for faithful maintenance. However, accurate preservation is often combined with regulated mechanisms that generate state change. Selectively advantageous instability (SAI) is modeled here as instability that is favored because useful alternatives…