21 papers · ranked by Valyu relevance
Rory M. Donovan-Maiye, Jackson M. Brown, Caleb K. Chan, Liya Ding + 7 more
'Calysta Yan' 'Nathalie Gaudreault' 'Julie A. Theriot' 'Mary M. Maleckar' 'Theo A. Knijnenburg' 'Gregory R. Johnson' 'Jeffrey J. Saucerman'] We introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures. We employ stacked…
Matheus P. Viana, Jianxu Chen, Theo A. Knijnenburg, Ritvik Vasan + 80 more
Understanding how a subset of expressed genes dictates cellular phenotype is a considerable challenge owing to the large numbers of molecules involved, their combinatorics and the plethora of cellular behaviours that they determine1,2. Here we reduced this complexity by focusing on cellular organization-a key readout…
Mary Mirvis, Brooke Weingard, Steven Goodman, Wallace F. Marshall
The level of cellular organization bridging the mesoscale and whole-cell scale is coming into focus as a new frontier in cell biology. Great progress has been made in unraveling the complex physical and functional interconnectivity of organelles, but how the entire organelle network spatially arranges within the…
S. Tori Ellison, Senthilkumar Duraivel, Vignesh Subramaniam, Kjell Fredrik Hugosson + 4 more
'Kjell Fredrik Hugosson' 'Joseph J. Lebowitz' 'Habibeh Khoshbouei' 'Mark Q. Martindale' 'Thomas E. Angelini'] In many tissues, cell type varies over single-cell length-scales, creating detailed spatial heterogeneities fundamental to physiological function. To gain understanding of this relationship between tissue…
Mary Mirvis, Brooke Weingard, Steven N. Goodman, Wallace F. Marshall
Background The level of cellular organization bridging the mesoscale and whole-cell scale is coming into focus as a key frontier in cell biology. Great progress has been made in unraveling the complex physical and functional interconnectivity of specific organelle pairs, but how the entire organelle network is…
Kevin Jerbic, Jan Taro Svejda, Benedikt Sievert, Andreas Rennings + 2 more
'Jürg Fröhlich' 'Daniel Erni'] Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are numerically challenging. For this reason, a method is…
Raphael Mostov, Greyson Lewis, Gabriel Sturm, Wallace F. Marshall
This paper addresses the increasing need for comprehensive mathematical descriptions of cell organization by examining the algebraic structure of mitochondrial network dynamics. Mitochondria are cellular structures involved in metabolism that take the form of a network of membrane-based tubes that undergo continuous…
Ernst Brücke, Daniel Liu
In 1861 the physiologist Ernst Brücke (1819-1892) published “The Elementary Organisms,” calling for a major reform of the definition of the animal cell. An English translation of Brücke’s essay is presented here for the first time. In this translation the numbered footnotes 1-9 are Brücke’s own; alphabetical endnotes…
Vishal S. Sivasankar, Roseanna N. Zia
The search for what differentiates inanimate matter from living things began in antiquity as a search for a "fundamental life force" embedded deep within living things — a special material unit owned only by life — later transforming to more circumspect search for unique gains in function that transform nonliving…
Eran Agmon
> Abstract: Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes. Whereas most systems biology models focus on the structure or dynamics of specific subsystems in controlled conditions, compositional systems biology aims to…
Qi Zhong, Chen-Xu Wu, Rui Ma
Walled cells, such as plants and fungi, compose an important part of the model systems in biology. The cell wall primarily functions to prevent the cell from over-expansion when exposed to water, and is a porous material distributed with nanosized pores on it. In this paper, we study the deformation of a membrane patch…
Sètuhn Jimaja, Andrea Belluati, Robert J. Chadwick, Christopher Glynn + 5 more
Artificial cells are biomimetic microstructures that mimic functions of natural cells and find application, e.g., as microreactors, as building blocks for molecular systems engineering, and to host synthetic biology pathways. Here, we report enzymatically synthesised polymer-based artificial cells with the ability to…
Satoshi Tsutsui, Winnie Pang, Shuting He, Bihan Wen
The microscopic examination of white blood cells (WBCs) plays a fundamental role in pathology and is essential for diagnosing blood disorders such as leukemia and anemia. To support further research on WBC images, multiple datasets have been proposed. However, they mainly annotate cell categories, and lack detailed…
Alexander Muacevic, John R Adler, Bruno Bordoni, Allan R Escher + 2 more
'Fabio Castellini' 'Joanna Vale'] The Foundation of Osteopathic Research and Clinical Endorsement (FORCE) is an organization that includes various figures involved in clinical and non-profit research and does not depend on any private or government body. To better understand how the human body behaves, we need to…
Fazlur Rashid, Ning Wang
Over the last few decades, physical principles have been proposed to explain some biological processes and functions. However, biological principles remain elusive. A biological principle is a governing rule that guides the structure and functions of cells. Biological principles are built upon the laws of physics and…
Selene M.C. Cannelli, Ritvik Gupta, Tan Nguyen, Arunava Poddar + 3 more
Liquid-liquid phase separation (LLPS) is a process that often occurs due to binding between oppositely charged biopolymers, and has gained increasing attention recently due to their ubiquity in biological systems and ability to direct essential cellular processes. For example, aberrant biological LLPS can lead to the…
Felix Mikus, Armando Rubio Ramos, Hiral Shah, Marine Olivetta + 17 more
Microbial eukaryotes are small and often resistant to standard labelling and imaging techniques, and therefore remain understudied – despite their critical ecological importance - with the exception of a few established models. Here, we use Ultrastructure Expansion Microscopy (U-ExM) to carry out high-resolution…
J. Rojas, Mayisha Z Nakib, Vivian Tang, William M. Brieher + 1 more
'Sascha Hilgenfeldt'] Two-dimensional (2D) mechanical models of confluent tissues have related the mechanical state of a monolayer of cells to the average perimeter length of the cell cross sections, predicting floppiness or rigidity of the material. For the well-studied system of in-vitro MDCK epithelial cells…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Uriah Israel, Markus Marks, Rohit Dilip, Qilin Li + 15 more
Cells are a fundamental unit of biological organization, and identifying them in imaging data – cell segmentation – is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress on this problem, most models are specialist models that work well for specific…
Authors not listed
The United Nations have committed to end the epidemics of communicable diseases by 2030 (SDG Target 3.3). In contrast with this ambition, the rise of Multi Drug Resistant (MDR) and Pan Drug Resistant (PDR) bacteria poses a threat of a return to the pre-antibiotic era. It is of high priority to find new therapies that…