Search · four archives
Search · four archives
7 papers · ranked by Valyu relevance
Kathleen S. Dreyer, Anh V. Nguyen, Gauri G. Bora, Lauren E. Redus + 6 more
Genetic programs can direct living systems to perform diverse, pre-specified functions. As the library of parts available for building such programs continues to expand, computation-guided design is increasingly helpful and necessary. Predictive models aid the challenging design process, but iterative simulation and…
Lillian T. Tatka, Lucian P. Smith, Herbert M. Sauro
Evolutionary algorithms, a class of optimization techniques inspired by biological evolution, have emerged as powerful tools for the optimization of complex systems, including the evolution of mass-action chemical reaction networks. This work explores the application of evolutionary algorithms in this domain…
Husanbir Singh Pannu, Douglas B. Kell
We analyse the effectiveness of differential evolution hyperparameters in large-scale search problems, i.e. those with very many variables or vector elements, using a novel objective function that is easily calculated from the vector/string itself. The objective function is simply the sum of the differences between…
Padavinangady Nakul Bhat, Debnath Pal
This study introduces a formal framework for modeling inheritance patterns based on an algebraic representation of genotype distributions. The approach defines genotypes as probability measures rather than discrete states, enabling the computation of genetic expectations, a probabilistic analogue that captures the…
Stefano Nolfi, Paolo Pagliuca
We investigate the use of competitive co-evolution for synthesizing progressively better solutions. Specifically, we introduce a set of methods to measure historical and global progress. We discuss the factors that facilitate genuine progress. Finally, we compare the efficacy of four qualitatively different algorithms.…
Patrícia Verdugo Pascoal, Deborah Bambil, Rayane N. Lima, Marco Antônio de Oliveira + 3 more
Quantum biology is an emergent field that investigates quantum-mechanical phenomena, such as superposition, tunneling, and entanglement, in the context of data manipulation from living systems. The exploration and engineering of nucleotide sequences rely on quantum mechanical principles, particularly the use of qubit…
Vaibhav Mohanty, Anna Sappington, Eugene I. Shakhnovich, Bonnie Berger
Classical population genetics has largely relied on the same stochastic differential equations (SDEs) for over 60 years to describe evolutionary dynamics. However, these SDEs ignore the fact that phenotype heterogeneity and noise are ubiquitous in biological systems from bacteria to cancers. Here, we develop…