14 papers · ranked by Valyu relevance
Charlotte K. Boughton, Roman Hovorka
Title: Graphical abstract Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually…
Felice T. Sun, Martha J. Morrell
Neurostimulation is now an established therapy for the treatment of movement disorders, pain, and epilepsy. While most neurostimulation systems available today provide stimulation in an open-loop manner (i.e., therapy is delivered according to preprogrammed settings and is unaffected by changes in the patient’s…
Steve M. Potter, Ahmed El Hady, Eberhard E. Fetz
Feedback and closed-loop circuits exist in just about every part of the nervous system. It is curious, therefore, that for decades neuroscientists have been probing the nervous system in an open-loop manner to understand it. Instead of the linear, reductionistic “stimulate → record response” approach, a more modern…
Mahboubeh Parastarfeizabadi, Abbas Z. Kouzani
Background Millions of patients around the world are affected by neurological and psychiatric disorders. Deep brain stimulation (DBS) is a device-based therapy that could have fewer side-effects and higher efficiencies in drug-resistant patients compared to other therapeutic options such as pharmacological approaches.…
Timothée Levi, Paolo Bonifazi, Paolo Massobrio, Michela Chiappalone
Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response…
Charlotte K. Boughton, Sara Hartnell, Janet M. Allen, Julia Fuchs + 1 more
'Roman Hovorka'] Hybrid closed-loop therapy is an emerging technology transforming the management of type 1 diabetes (T1D). Research studies demonstrate glycemic and quality of life benefits of hybrid closed-loop therapy for people with T1D. Translating these outcomes into standard clinical practice is critical for…
Charlotte K. Boughton, Lia Bally, Roman Hovorka
The prevalence of diabetes in the hospital is increasing and approximately 18-20% of hospital beds are occupied by someone with diabetes . Diabetes disproportionally affects the elderly, with three times greater prevalence in hospitalised people aged over 65 years than in those aged under 45 years . Maintaining near…
Shriya S. Srinivasan, Benjamin E. Maimon, Maurizio Diaz, Hyungeun Song + 1 more
'Hyungeun Song' 'Hugh M. Herr'] Optogenetics has been used to orchestrate temporal- and tissue-specific control of neural tissues and offers a wealth of unique advantages for neuromuscular control. Here, we establish a closed-loop functional optogenetic stimulation (CL-FOS) system to control ankle joint position in…
Yorinari Ochiai, Minoru Oda, Junji Tanaka, Yusuke Kawai + 3 more
Endoscopic submucosal dissection (ESD) is widely performed for early gastrointestinal tumors; however, delayed bleeding is a major complication, reported in 5-10% of cases 1 . Various closure methods after ESD may reduce delayed bleeding 23 . We have developed and used a novel closure technique named “closure on…
Bruno Burlando
Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity…
Ahmed A. Aljorfi, Abdulhameed H. Alkhamis
Introduction A Loop ileostomy is one of the most common techniques used in colorectal surgery to establish a reversible faecal diversion and bypass the large bowels, in order to protect either a downstream colorectal anastomosis or a coloanal anastomosis. However, it is a procedure that can cause a plethora of…
Odd V. Höglund, Oskar Maxon, Anders Grönberg
Background Colorectal cancer is common in humans where treatment involves surgical removal of the cancerous part of the intestines. In the anastomosis procedure a purse-string suture may be time consuming to perform. The aim was to replace the purse-string suture, to develop and test a self-locking loop for temporary…
Kazuo Shiotsuki, Kohei Takizawa, Yohei Nose, Yuki Kondo + 10 more
'Hitoshi Homma' 'Taisuke Inada' 'Mao Daikaku' 'Kosuke Maehara' 'Shin-ichiro Fukuda' 'Hironori Aoki' 'Yorinobu Sumida' 'Hirotada Akiho' 'Jiro Watari' 'Kiyokazu Nakajima'] Background and study aims Development of a simple, optimized closure method for mucosal defects left by gastric endoscopic submucosal dissection (ESD)…
Akira Yoshida, Hiroki Kurumi, Yuichiro Ikebuchi, Koichiro Kawaguchi + 8 more
'Kazuo Yashima' 'Yu Kamitani' 'Sho Yasui' 'Yusuke Nakada' 'Tsutomu Kanda' 'Tomoaki Takata' 'Hajime Isomoto' 'Emmanuel Andrès'] Endoscopic submucosal dissection (ESD) and en bloc resection of stomach and colon tumors have become common. However, mucosal defects resulting from ESD may cause delayed bleeding and…