12 papers · ranked by Valyu relevance
Charlotte K. Boughton, Roman Hovorka
Title: Graphical abstract Advances in diabetes technologies have enabled the development of automated closed-loop insulin delivery systems. Several hybrid closed-loop systems have been commercialised, reflecting rapid transition of this evolving technology from research into clinical practice, where it is gradually…
Felice T. Sun, Martha J. Morrell
Neurostimulation is now an established therapy for the treatment of movement disorders, pain, and epilepsy. While most neurostimulation systems available today provide stimulation in an open-loop manner (i.e., therapy is delivered according to preprogrammed settings and is unaffected by changes in the patient’s…
Steve M. Potter, Ahmed El Hady, Eberhard E. Fetz
Feedback and closed-loop circuits exist in just about every part of the nervous system. It is curious, therefore, that for decades neuroscientists have been probing the nervous system in an open-loop manner to understand it. Instead of the linear, reductionistic “stimulate → record response” approach, a more modern…
Mahboubeh Parastarfeizabadi, Abbas Z. Kouzani
Background Millions of patients around the world are affected by neurological and psychiatric disorders. Deep brain stimulation (DBS) is a device-based therapy that could have fewer side-effects and higher efficiencies in drug-resistant patients compared to other therapeutic options such as pharmacological approaches.…
Deepak K. Agrawal, Ryan Marshall, Vincent Noireaux, Eduardo D Sontag
Feedback mechanisms play a critical role in the maintenance of cell homeostasis in the presence of disturbances and uncertainties. Motivated by the need to tune the dynamics and improve the robustness of gene circuits, biological engineers have proposed various designs that mimic natural molecular feedback control…
Charlotte K. Boughton, Sara Hartnell, Janet M. Allen, Julia Fuchs + 1 more
'Roman Hovorka'] Hybrid closed-loop therapy is an emerging technology transforming the management of type 1 diabetes (T1D). Research studies demonstrate glycemic and quality of life benefits of hybrid closed-loop therapy for people with T1D. Translating these outcomes into standard clinical practice is critical for…
Ehud Ahissar, Eldad Assa, David Kleinfeld
Perception of external objects involves sensory acquisition via the relevant sensory organs. A widely-accepted assumption is that the sensory organ is the first station in a serial chain of processing circuits leading to an internal circuit in which a percept emerges. This open-loop scheme, in which the interaction…
Timothée Levi, Paolo Bonifazi, Paolo Massobrio, Michela Chiappalone
Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response…
Charlotte K. Boughton, Lia Bally, Roman Hovorka
The prevalence of diabetes in the hospital is increasing and approximately 18-20% of hospital beds are occupied by someone with diabetes . Diabetes disproportionally affects the elderly, with three times greater prevalence in hospitalised people aged over 65 years than in those aged under 45 years . Maintaining near…
John M. Flach, John S. Carroll, Marvin J. Dainoff, W. Ian Hamilton
How do communications and decisions impact the safety of sociotechnical systems? This paper frames this question in the context of a dynamic system of nested sub-systems. Communications are related to the construct of observability (i.e. how components integrate information to assess the state with respect to local and…
Shriya S. Srinivasan, Benjamin E. Maimon, Maurizio Diaz, Hyungeun Song + 1 more
'Hyungeun Song' 'Hugh M. Herr'] Optogenetics has been used to orchestrate temporal- and tissue-specific control of neural tissues and offers a wealth of unique advantages for neuromuscular control. Here, we establish a closed-loop functional optogenetic stimulation (CL-FOS) system to control ankle joint position in…
Bruno Burlando
Despite intensive investigations numerous diseases remain etiologically puzzling and recalcitrant to treatments. A hypothesis is proposed here assuming that these difficulties are due to an unsuitable approach to the mechanisms of life, which is subjugated by an apparent complexity and fails to grasp the uniformity…