12 papers · ranked by Valyu relevance
Ben C. Shirley, Eliseos J. Mucaki, Joan H.M. Knoll, Peter K. Rogan
Rapid sample processing and interpretation of estimated exposures will be critical for triaging exposed individuals after a major radiation incident. The dicentric chromosome (DC) assay assesses absorbed radiation using metaphase cells from blood. The Automated Dicentric Chromosome Identifier and Dose Estimator System…
Christiam Camacho, Grzegorz M. Boratyn, Victor Joukov, Roberto Vera Alvarez + 1 more
Biomedical researchers use alignments produced by BLAST (Basic Local Alignment Search Tool) to categorize their query sequences. Producing such alignments is an essential bioinformatics task that is well suited for the cloud. The cloud can perform many calculations quickly as well as store and access large volumes of…
Joseph Giustizia, Wilson Hodgson, Cameron Andress, Satpal Bilkhu + 2 more
As sequencing technologies have matured, bioinformatics tasks have become more complex, computationally demanding, and data intensive. Workflow management software has been developed to aid in simplifying the replicable chaining of complex bioinformatics jobs, and cloud computing has emerged as a potential solution to…
Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin + 34 more
Genomic researchers are increasingly utilizing commercial cloud platforms (CCPs) to manage their data and analytics needs. Commercial clouds allow researchers to grow their storage and analytics capacity on demand, keeping pace with expanding project data footprints and enabling researchers to avoid large capital…
Ling-Hong Hung, Niharika Nasam, Wes Lloyd, Ka Yee Yeung
Singe cell RNA sequencing (scRNA-seq) has become a routine method for measuring cell activities. Processing large scRNA-seq datasets requires high-performance computing resources. The emergence of cloud computing allows us to leverage its on-demand capabilities without major investment in infrastructure. Serverless…
Ling-Hong Hung, Niharika Nasam, Chris Biju, Wes Lloyd + 1 more
Singe cell RNA sequencing (scRNA-seq) has become a routine method for measuring cell activities. Processing large scRNA-seq datasets requires high-performance computing resources. The emergence of cloud computing allows us to leverage its on-demand capabilities without major investment in infrastructure. Serverless…
Jinghui Geng, Kateryna Voitiuk, David F. Parks, Ash Robbins + 15 more
Electrophysiology offers a high-resolution method for real-time measurement of neural activity. Longitudinal recordings from high-density microelectrode arrays (HD-MEAs) can be of considerable size for local storage and of substantial complexity for extracting neural features and network dynamics. Analysis is often…
Konrad Rokicki, David Schauder, Donald J. Olbris, Cristian Goina + 8 more
HortaCloud is a cloud-based, open-source platform designed to facilitate the collaborative reconstruction of long-range projection neurons from whole-brain light microscopy data. By providing virtual environments directly within the cloud, it eliminates the need for costly and time-consuming data downloads, allowing…
Taner Karagöl, Alper Karagöl
Molecular dynamics (MD) simulations are widely used computational tools in chemical and biological sciences. For these simulations, GROMACS is a popular open-source alternative among molecular dynamics simulation software designed for biochemical molecules. In addition to software, these simulations traditionally…
Tyson L. Swetnam, Parker B. Antin, Ryan Bartelme, Alexander Bucksch + 44 more
CyVerse, the largest publicly-funded open-source research cyberinfrastructure for life sciences, has played a crucial role in advancing data-driven research since the 2010s. As the technology landscape evolved with the emergence of cloud computing platforms, machine learning and artificial intelligence (AI)…
Yujue Li, Fei Xue, Bingxuan Li, Yilin Yang + 6 more
As large-scale biobanks provide increasing access to deep phenotyping and genomic data, genome-wide association studies (GWAS) are rapidly uncovering the genetic architecture behind various complex traits and diseases. GWAS publications typically make their summary-level data (GWAS summary statistics) publicly…
Kevin Kang, Jinwen Wo, Jon Jiang, Zhong Wang
We propose Adaptive Container Service (ACS), a new paradigm for deploying bioinformatics workflows in cloud computing environments. By encapsulating the entire workflow within a single virtual container, combined with automatic workflow checkpointing and dynamic migration to appropriately scaled containers, ACS-based…